Summary
The plasma kinetics and elimination of folic acid were studied in 11 healthy subjects after saturation with a multivitamin preparation. A radioassay was utilized for the determination of folic acid. After the i.m. injection of 1.1 mg folic acid sodium, a maximum plasma level of 63.7±14.3 nmol/l was reached after 0.69±0.26 h. The elimination half-life time amounted to 1.53±0.46 h. Based on the injected amount of folic acid, the cumulative increase in elimination within 24 h amounted to 9.4%±3.1%. Within the first 6 h 81.4%±6.1% of the administered folic acid appeared in the urine and in the following 4 h 17.3%±5.4%.
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Loew, D., Eberhardt, A., Heseker, H. et al. Zur Plasmakinetik und Elimination von Folsäure. Klin Wochenschr 65, 520–524 (1987). https://doi.org/10.1007/BF01721039
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DOI: https://doi.org/10.1007/BF01721039