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Prevalence of antibodies toYersinia enterocolitica O:3 among Norwegian military recruits: Association with risk factors and clinical manifestations

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Abstract

IgG antibody activity toYersinia enterocolitica serogroup O:3 was detected in sera from 56 (7.4%) of 755 Norwegian military recruits, using an enzyme-linked immunosorbent assay. The highest prevalence was found among recruits from Oslo city (12/56, 21.4%). The recruits answered a questionnaire which covered demographic data, specific exposures, and clinical information. The following risk factors were found to be independently associated with IgG activity in logistic regression analysis: receiving drinking water from a private well (odds ratio (OR)=3.40;p=0.004), being a resident of Oslo city (OR=2.99;p=0.006), and living in eastern Norway (OR=2.25;p=0.015). By univariate analysis, living in an urban area was associated with IgG activity, but this factor did not independently affect risk. Present or previous contact with animals, including pigs, and travels abroad were not associated with an increased risk.Yersinia enterocolitica O:3 seropositive recruits were more likely to report previous surgery for suspected appendicitis than seronegative individuals (OR=4.26;p=0.0024). Among recruits with previous appendectomy, mesenteric lymphadenitis as the sole peroperative finding was more common in patients with IgG activity to Y. enterocolitica O:3 (4/7) than in seronegative patients (1/19) (p=0.01). Recurrent diarrhea, steatorrhea or joint complaints were not associated with antibody activity.

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References

  1. Agner E, Eriksen M, Hollnagel H, Larsen JH, Mørck HI, Schroll M. Prevalence of raisedYersinia enterocolitica antibody titre in unselected, adult populations in Denmark during 12 years. Acta Med Scand 1981; 209: 509–512.

    Google Scholar 

  2. Aho K, Ahvonen P, Lassus A, Sievers K, Tiilikainen A. HL-A27 in reactive arthritis: A study ofYersinia arthritis and Reiter's disease. Arthritis Rheum 1974; 17: 521–526.

    Google Scholar 

  3. Ahvonen P. Human yersiniosis in Finland, II: Clinical features. Ann Clin Res 1972; 4: 39–48.

    Google Scholar 

  4. Arvastson B, Damgaard K, Winblad S. Clinical symptoms of infection withYersinia enterocolitica. Scand J Infect Dis 1971; 3: 37–40.

    Google Scholar 

  5. Bellmann A, Bellman KP. Untersuchungen über die Inzidenz der Infectionen mitYersinia enterocolitica bei verschiedenen Formen der Appendizitis, der cholelithiasis und Patienten mit euthyreoten und hyperthyreoten Struma. Zentralbl Chir 1980; 105: 974–981.

    Google Scholar 

  6. Black RE, Slome S.Yersinia enterocolitica. Infect Dis Clin North Am 1988; 2: 625–641.

    Google Scholar 

  7. Brennhovd O, Kapperud G, Langeland G. Survey of thermotolerantCampylobacter spp. and Yersinia spp. in three surface water sources in Norway. Int J Food Microbiol 1992; 15: 327–338.

    Google Scholar 

  8. Carlsson HE, Hurvell B, Lindberg AA. Enzyme-linked immunosorbent assay (ELISA) for titration of antibodies againstBrucella abortus andYersinia enterocolitica. Acta Pathol Microbiol Immunol Scand (sect. C) 1976; 84: 168–176.

    Google Scholar 

  9. Carlsson MG, Ryd H, Sternby NH. A case of human infection withPasteurella pseudotuberculosis X. Acta Pathol Microbiol Scand 1964; 62: 128–132.

    Google Scholar 

  10. Corbel MJ. The relationship between the protective and cross-reacting antigens ofBrucella spp.,Yersinia enterocolitica O:9 andSalmonella serotypes of Kaufmann-White group N. Contrib Microbiol Immunol 1979; 5: 50–63.

    Google Scholar 

  11. Cover TL, Aber RC.Yersinia enterocolitica. N Engl J Med 1989; 321: 16–24.

    Google Scholar 

  12. Friedberg M, Denneberg T, Brun C, Larsen JH, Larsen S. Glomerulonephritis in infection withYersinia enterocolitica O-serotype 3, II: The incidence and immunological features of Yersinia infection in a consecutive glomerulonephritis population. Acta Med Scand 1981; 209: 103–110.

    Google Scholar 

  13. Hurvell B. ZoonoticYersinia enterocolitica infection: Host range, clinical manifestations, and transmission between animals and man. In: Bottone EJ, ed.Yersinia enterocolitica. Boca Raton, Fl: CRC Press, 1981: 145–159.

    Google Scholar 

  14. Jepsen OB, Korner B, Lauritsen KB, Hancke AB, Andersen L, Henrichsen S, Brenøe E, Christiansen PM, Johansen A.Yersinia enterocolitica infection in patients with acute surgical abdominal disease: A prospective study. Scand J Infect Dis 1976; 8: 189–194.

    Google Scholar 

  15. Kapperud G.Yersinia enterocolitica andYersinia like microbes isolated from mammals and water in Norway and Denmark. Acta Pathol Microbiol Immunol Scand (sect. B) 1977; 85: 129–135.

    Google Scholar 

  16. Kapperud G, Jonsson B.Yersinia enterocolitica et bactéries apparentées isolées à partir d'écosystèmes d'eau douce en Norvège. Méd Mal Infect 1978; 8: 500–506.

    Google Scholar 

  17. Kapperud G, Bergan T. Biochemical and serological characterization ofYersinia enterocolitica. In: Bergan T, Norris JR, eds. Methods in microbiology, Vol. 15. London: Academic Press, 1984; 295–344.

    Google Scholar 

  18. Kapperud G.Yersinia enterocolitica in food hygiene. Int J Food Microbiol 1991; 12: 53–66.

    Google Scholar 

  19. Langeland G.Yersinia enterocolitica and Yersinia enterocolitica-like bacteria in drinking water and sewage sludge. Acta Pathol Microbiol Immunol Scand (sect. B) 1983; 91: 179–185.

    Google Scholar 

  20. Larsen JH.Yersinia enterocolitica infection and rheumatic diseases. Scand J Rheumatol 1980; 9: 129–137.

    Google Scholar 

  21. Lassen J.Yersinia enterocolitica in drinking-water. Scand J Infect Dis 1972: 4: 125–127.

    Google Scholar 

  22. Leino R, Kalliomäki JL. Yersiniosis as an internal disease. Ann Intern Med 1974; 81: 458–461.

    Google Scholar 

  23. Leirisalo M, Skylv G, Kousa M, Voipo-Pulkki LM, Souranta H, Nissila M, Hvidman L, Nielsen ED, Svejgaard A, Tiilikaninen A, Laitinen O. Follow-up study on patients with Reiter's disease and reactive arthritis, with special reference to HLA-B27. Arthritis Rheum 1982; 25: 249–259.

    Google Scholar 

  24. Mollaret HH, Bercovier H, Alonso JM. Summary of the data received at the WHO Reference Center forYersinia enterocolitica. Contrib Microbiol Immunol 1979; 5: 174–184.

    Google Scholar 

  25. Nesbakken T, Kapperud G.Yersinia enterocolitica and Yersinia enterocolitica-like bacteria in Norwegian slaughter pigs. Int J Food Microbiol 1985; 1: 301–309.

    Google Scholar 

  26. Nilehn B, Sjöström B. Studies onYersinia enterocolitica. Occurence in various groups of acute abdominal disease. Acta Pathol Microbiol Scand 1967; 71: 612–628.

    Google Scholar 

  27. Nilehn B. Studies onYersinia enterocolitica. With special reference to bacterial diagnosis and occurence in human enteric disease. Acta Pathol Microbiol Scand 1969; 206 (suppl): 1–48.

    Google Scholar 

  28. Ostroff SM, Kapperud G, Lassen J, Aasen S, Tauxe RV. Clinical features of sporadicYersinia enterocolitica infections in Norway. J Infect Dis 1992; 166: 812–817.

    Google Scholar 

  29. Ostroff SM, Kapperud G, Hutwagner LC, Nesbakken T, Hargrett-Bean N, Lassen J, Tauxe RV. Sources of sporadicYersinia enterocolitica infections in Norway: A prospective case-control study. Epidemiol Infect 1994; 112: 133–141.

    Google Scholar 

  30. Puylaert JBCM, Vermeijden RJ, van der Werf SDJ, Doornbos L, Koumans RKJ. Incidence and sonographic diagnosis of bacterial ileocaecitis masquerading as appendicitis. Lancet 1989 (ii): 84–86.

  31. Schiemann DA.Yersinia enterocolitica andYersinia pseudotuberculosis. In: Doyle MP, ed. Foodborne bacterial pathogens. New York: Marcel Dekker, 1989: 601–672.

    Google Scholar 

  32. Sotaniemi KA. Neurologic complications associated with yersiniosis. Neurology 1983; 33: 95–97.

    Google Scholar 

  33. Sæbø A. Liver affection associated withYersinia enterocolitica infection. Acta Chir Scand 1977; 143: 445–450.

    Google Scholar 

  34. Sæbø A, Lassen J. A survey of acute and chronic disease associated withYersinia enterocolitica infection. A Norwegian 10-year follow-up study on 458 hospitalized patients. Scand J Infect Dis 1991; 23: 517–527.

    Google Scholar 

  35. Sæbø A, Lassen J. Acute and chronic gastrointestinal manifestations associated withYersinia enterocolitica infection: A Norwegian 10-year follow-up study on 458 hospitalized patients. Ann Surg 1992; 215: 250–255.

    Google Scholar 

  36. Swaminathan B, Harmon MC, Mehlman IJ. A review —Yersinia enterocolitica. J Appl Bacteriol 1982; 52: 151–183.

    Google Scholar 

  37. Van Noyen R, Selderslaghs R, Bekaert J, Wauters G, Vandepitte J. Causative role ofYersinia and other enteric pathogens in the appendicular syndrome. Eur J Clin Microbiol Infect Dis 1991; 10: 735–741.

    Google Scholar 

  38. Westphal O, Lüderitz O, Bister F. Über die Extraktion von Bakterien mit Phenol-Wasser. Z Naturforsch 1952; 7: 148–155.

    Google Scholar 

  39. Winblad S, Nilehn B, Sternby NH.Yersinia enterocolitica (Pasteurella X) in human enteric infections. Br Med J 1966; 2: 1363–1366.

    Google Scholar 

  40. World Health Organization. Yersiniosis — Report on a WHO meeting. EURO reports and studies 60. Copenhagen: WHO Regional Office for Europe, 1983: 4–9.

    Google Scholar 

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Authors and Affiliations

  1. Institute of Surgery, University of Bergen, Bergen, Norway

    Arve Sæbø

  2. Department of Bacteriology, National Insitute of Public Health, Oslo, Norway

    Georg Kapperud & Jørgen Lassen

  3. Norwegian Defence Microbiological Laboratory, Oslo, Norway

    Georg Kapperud

  4. Royal Norwegian Naval Training Camp Harald Hårfagre, Hafrsfjord, Norway

    Jan Waage

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  1. Arve Sæbø
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  2. Georg Kapperud
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  4. Jan Waage
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Sæbø, A., Kapperud, G., Lassen, J. et al. Prevalence of antibodies toYersinia enterocolitica O:3 among Norwegian military recruits: Association with risk factors and clinical manifestations. Eur J Epidemiol 10, 749–755 (1994). https://doi.org/10.1007/BF01719293

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