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Evidence for involvement of equine herpesvirus 1 glycoprotein B in cell-cell fusion

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Summary

Monoclonal antibodies specific for equine herpesvirus 1 (EHV-1) glycoproteins (gB, gD, gp2 and a cleaved translation product of gene 71) were tested for ability to inhibit cell-cell fusion as measured by syncytium formation in EHV-1 infected cell cultures. Syncytium formation was inhibited by a complement-dependent neutralising antibody (7B10) which recognised the large subunit of EHV-1 gB. This indicated that EHV-1 gB, in common with gB homologues of herpes simplex virus and other herpesviruses, plays a role in the cell-cell fusion process.

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Authors and Affiliations

  1. School of Biological Sciences, Macquarie University, Sydney

    J. E. Wellington & J. M. Whalley

  2. Department of Veterinary Pathology, University of Sydney, New South Wales, Australia

    D. N. Love

Authors
  1. J. E. Wellington
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  2. D. N. Love
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  3. J. M. Whalley
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Wellington, J.E., Love, D.N. & Whalley, J.M. Evidence for involvement of equine herpesvirus 1 glycoprotein B in cell-cell fusion. Archives of Virology 141, 167–175 (1996). https://doi.org/10.1007/BF01718598

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  • DOI: https://doi.org/10.1007/BF01718598

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