Summary
We determined the nucleotide sequence of the SH gene and its flanking regions over a range of 380 nucleotides for three distinct mumps virus (MUV) isolates. Two isolates from the 1992 mumps epidemic in Western Switzerland and one MUV isolated in 1995 in the same geographic area have been analyzed and compared to 16 recently published SH nucleotide sequences and their presumed amino acid sequences. The nucleotide sequences from the 1992 MUV isolates were identical and closely related to two MUV strains from Eastern Switzerland and strains from the U.K. The MUV isolated in 1995 is clearly different from all other strains.
This is a preview of subscription content, log in via an institution to check access.
References
Takeuchi K, Tanabayashi K, Hishiyama M, Yamada YK, Yamada A, Sugiura A (1990) Detection and characterization of mumps virus V protein. Virology 178: 247–253
Elango N, Varsanyi TM, Kövamees J, Norrby E (1988) Molecular cloning and characterization of six genes, determination of gene order and intergenic sequences and leader sequence of mumps virus. J Gen Virol 69: 2893–2900
Yeo RP, Afzal MA, Forsey T, Rima BK (1993) Identification of a new mumps virus lineage by nucleotide sequence analysis of the SH gene of 10 different strains. Arch Virol 128: 371–377
Yamada A, Takeuchi K, Tanabayashi K, Hishiyama M, Sugiura A (1989) Sequence variation of the P gene among mumps virus strains. Virology 172: 374–376
Künkel U, Driesel G, Henning U, Gerike E, Willers H, Schreier E (1995) Differentiation of vaccine and wild mumps viruses by polymerase chain reaction and nucleotide sequencing of the SH gene: brief report. J Med Virol 45: 121–126
Künkel U, Schreier E, Siegl G, Schultze D (1994) Molecular characterization of mumps virus strains circulating during an epidemic in Eastern Switzerland 1992/93. Arch Virol 136: 433–438
Glück R (1987) Procedure for the adaption of the new mumps vaccine strain ‘rubini’ to human diploid cells. In: Spier RE, Griffiths JB (eds) Modern approaches to animal cell technology. Butterworth, Sevenoaks, pp 587–595
Deiss V, von Overbeck J, Furrer H-J, Germann D, Matter L, Telenti A (1994) Die Epidemiologie der HIV-1-Infektion in Bern — Anwendung molekularer Methoden. Schweiz Med Wochenschr 124: 539–544
Telenti A, Imboden P, Germann D (1992) Competitive polymerase chain reaction using an internal standard: application to the quantitation of viral DNA. J Virol Methods 39: 259–268
Elliott GD, Afzal MA, Martin SJ, Rima BK (1989) Nucleotide sequence of a matrix fusion and putative SH protein genes of mumps virus and their deduced amino acid sequences. Virus Res 12: 61–75
Takeuchi K, Tanabayashi K, Hishiyama M, Yamada A, Sugiura A (1991) Variations of nucleotide sequences and transcription of the SH gene among mumps virus strains. Virology 181: 364–366
Afzal MA, Pickford AR, Forsey T, Heath AB, Minor PD (1993) The Jeryl Lynn vaccine strain of mumps virus is a mixture of two distinct isolates. J Gen Virol 74: 917–920
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ströhle, A., Bernasconi, C. & Germann, D. A new mumps virus lineage found in the 1995 mumps outbreak in Western Switzerland identified by nucleotide sequence analysis of the SH gene. Archives of Virology 141, 733–741 (1996). https://doi.org/10.1007/BF01718331
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01718331