Summary
Peripheral blood lymphocytes (PBL) from cats infected with feline immunodeficiency virus (FIV) were examined for the occurrence of apoptosis after short-term culture. In the PBL from FIV-infected cats, changes in flow-cytometry scattergram, morphological characteristics of apoptosis and nucleosomal DNA fragmentation were observed. Percentages of apoptotic cells by flowcytometry analysis in PBL from FIV-infected cats (22.4%±9.4%) were significantly higher than those in PBL from uninfected control cats (9.2%±3.5%). The lymphocytes which underwent apoptosis included CD5+, CD4+ and sIgM+ cells, indicating that induction of apoptosis was not restricted to a special subset of lymphocytes. These findings provide evidence of the apoptotic state of PBL in cats with FIV infection.
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Momoi, Y., Mizuno, T., Nishimura, Y. et al. Detection of apoptosis induced in peripheral blood lymphocytes from cats infected with feline immunodeficiency virus. Archives of Virology 141, 1651–1659 (1996). https://doi.org/10.1007/BF01718289
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DOI: https://doi.org/10.1007/BF01718289