Summary
Marburg virus (MV) reproduction in organs, hematological and pathological changes were studied by virological and clinical methods, light and electron microscopy in guinea pigs respiratory challenged by the virus. Liver and spleen were most affected by MV, as in parenteral infection. The sequential involvement of cells in virus replication was also the same as in parenteral infection, with monocytoid-macrophagal cells infected first, followed by hepatocytes, spongiocytes, endotheliocytes and fibroblasts. Hemopoietic cells showed evidence of severe damage in respiratory infected guinea pigs. A distinguishing feature of the respiratory infection was close contact of leucocytes with MV infected cells. It is suggested that the entrapment and accumulation of MV in the lungs of respiratory infected guinea pigs makes possible the enfoldment leucocyte attack which does not, however, result in destruction of the infected cells.
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References
Akira S, Tetsuya T, Kishimoto T (1993) Interleukin-6 in biology and medicine. Adv Immunol 54: 1–5
Bogdan C, Nathan C (1993) Modulation of macrophage function by transforming growth factor b, interleukin-4 and interleukin-10. Ann NY Acad Sci 685: 713–716
Edwards RL, Rickles FR (1984) Macrophage procoagulants. Prog Hemost Thromb 7: 183–209
Fisher-Hoch SP, Brammer L, Trappier SG, Hutwagner LC, Farrar BB, Ruo SL, Brown BG, Hermann LM, Perez-Oronoz GI, Goldsmith CS, Hanes MA, McCormick JB (1992) Pathogenic potential of filoviruses: role of geographic origin of primate host and virus strain. J Infect Dis 166: 753–763
Gear JHS (1989) Clinical aspects of African viral hemorrhagic fevers. Rev Infect Dis 11 [Suppl 4]: S777–782
Gedick P, Bechtelsteimer H, Korb G (1971) Pathologic anatomy of the Marburg virus disease. In: Martini GA, Siegert R (eds) Marburg virus disease. Springer, Berlin Heidelberg New York, pp 50–53
Geisbert TW (1992) Assosiation of Ebola related Reston virus particles and antigen with tissue lesions of monkeys imported to the United States. J Comp Pathol 106: 137–152
Guyton AC (1947) Measurement of respiratory volumes of laboratory animals. Am J Physiol 150: 70–77
Hume D, Gordon S (1982) Macrophage biochemistry. Life Chem Rep 1: 1–47
Jahrling PB, Geisbert TW, Dalgard DW, Johnson ED, Ksiazek TG, Hall WC, Peters CJ (1990) Preliminary report: isolation of Ebola virus from monkeys imported to USA. Lancet 335: 502–505
Korb G, Slenczka W, Bechtelsheimer H, Gedick P (1971) Die “Marburg-Virus”-Hepatitis im Tierexperiment. Virch Arch Abt A Path Anat 353: 169–184
Korb G, Slenczka W (1971) Histologic findings in liver and spleens of guinea pigs after infection by the Marburg virus. In: Martini GA, Siegert R (eds) Marburg virus disease. Springer, Berlin Heidelberg New York, pp 123–124
Lub MYu, Sergeev AN, Pyankova OG, Pyankov OV, Petricshenko VA, Kotlyarov LA (1995) Clinical and virologic characterization of the disease in guinea pigs aerogenically infected with Marburg virus. Probl Virol 3: 119–121
Murphy FA, Simpson DIH, Whitefield SC, Zlotnik I, Carter GB (1971) Marburg virus infection in monkeys. Ultrastructural studies. Lab Invest 24: 279–291
Nikiforov VV, Turovski YuI, Kalinin PP, Akinfeeva LA, Katkova LR, Barmin VC, Ryabchikova EI, Popkova NI, Shestopalov AM, Nazarov VP, Vedizshev SV, Netesov SV (1994) A case of laboratory infection with Marburg hemorrhagic fever. J Microbiol Epidemiol Immunol 3: 104–106
Peters D, Johnson ED, McKee KT (1991) Filoviruses and management and viral hemorrhagic fevers. In: Belshe RB (ed) Textbook of human virology. Mosby Year Book, St. Louis, pp 699–712
Pokhodyaev VA, Gonchar NI, Pshenichnov VA (1991) Experimental study of Marburg virus contact transmission. Probl Virol 6: 506–508
Roberts R, Gallagher J, Spoonger E, Allen TD, Bloomfield FA, Dexter TM (1988) Heparan sulphate bound growth factors: a mechanism for stromal cell mediated haemopoiesis. Nature 332: 376–378
Ryabchikova EI, Vorontsova LA, Skripchenko AA, Shestopalov AM, Sandahchiev LS (1994) The peculiarities of internal organs damage in experimental animals infected with Marburg disease virus. Bull Exp Biol Med 4: 430–434
Siegert R (1972) Marburg virus. Virol Monogr 11: 98–153
Skripchenko AA, Ryabchikova EI, Vorontsova LA, Shestopalov AM, Vyazunov SA (1994) Marburg virus and mononuclear phagocytes: study of interaction. Probl Virol 5: 215–219
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Ryabchikova, E., Strelets, L., Kolesnikova, L. et al. Respiratory Marburg virus infection in guinea pigs. Archives of Virology 141, 2177–2190 (1996). https://doi.org/10.1007/BF01718224
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DOI: https://doi.org/10.1007/BF01718224