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Histamine and some of its metabolites in human body fluids

Histamin und einige seiner Metaboliten in menschlichen Körperflüssigkeiten

  • 1. Adverse Reactions And Histamine Release In Anaesthesia And Surgery
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Summary

The concentrations of histamine, t-methylhistamine and t-methylimidazoleacetic acid were measured in human cerebrospinal fluid, plasma and urine, Especially noteworthy are the levels of histamine in cerebrospinal fluid which are far higher than those of t-methylhistamine and of t-methylimidazoleacetic acid, and high enough to stimulate histamine receptors in the central nervous system. It is suggested that mast cells, which surround the subarachnoid space, may contribute histamine to the cerebrospinal fluid and may offer a target for drugs and for immunologic actions. The t-methylhistamine and t-methylimidazoleacetic acid levels in cerebrospinal fluid may reflect central histaminergic activity, although a source of these metabolites in addition to histamine needs to be considered.

Zusammenfassung

Die Konzentrationen von Histamin, t-Methylhistamin, t-Methylimidazolessigsäure wurden in menschlichen zerebrospinalen Flüssigkeiten, im Plasma und im Urin gemessen. Beachtenswert sind insbesondere die Histaminspiegel in zerebrospinaler Flüssigkeit, die sehr viel höher als die Spiegel von t-Methylhistamin und t-Methylimidazolessigsäure sind. Sie sind hoch genug, um Histaminrezeptoren im zentralen Nervensystem zu stimulieren. Es wird nahegelegt, daß Mastzellen, die den subarachnoidalen Raum umgeben, das Histamin in die zerebrospinale Flüssigkeit abgeben und deshalb ein Ziel für Arzneimittel und immunologische Vorgänge darstellen. Die t-Methylhistamin-und t-Methylimidazolessigsäurespiegel in der Zerebrospinalflüssigkeit könnten die zentrale Histaminaktivität widerspiegeln, obgleich ein Ursprung dieser Metaboliten zusätzlich zum Histamin berücksichtigt werden sollte.

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  1. Dept. of Pharmacology, Mount Sinai School of Medicine, City University of New York, 10029, New York, NY, USA

    J. K. Khandelwal Ph.D., L. B. Hough & J. P. Green

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  1. J. K. Khandelwal Ph.D.
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  2. L. B. Hough
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  3. J. P. Green
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Supported by a grant (MH-31805) from the National Institute of Mental Health

Statistical analyses and curve fitting were performed on the PROPHET computer system, a national resource supported by the Chemical-Biological Information Handling Program, Division of Research Resources, National Institutes of Health

Recipient of the Faculty Development Award in Pharmacology from the Pharmaceutical Manufacturers Association

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Khandelwal, J.K., Hough, L.B. & Green, J.P. Histamine and some of its metabolites in human body fluids. Klin Wochenschr 60, 914–918 (1982). https://doi.org/10.1007/BF01716947

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