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Carriage of antibiotic-resistantEscherichia coli by healthy volunteers during a 15-week period

Trägertum Antibiotika-resistenterEscherichia coli bei gesunden Freiwilligen während 15 Wochen

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Summary

Escherichia coli strains (n=678 and n=670) isolated from faecal samples from 90 and 93 healthy volunteers of two cities, Weert and Roermond respectively, were analysed for their susceptibility to 12 antimicrobial agents during a 15-week period. Significant differences between both cities in the distribution of the MIC values were observed for apramycin, chloramphenicol, kanamycin, neomycin, nitrofurantoin, sulfamethoxazole and trimethoprim. For Weert (n=678) the antibiotic resistance percentages varied from 0.4% for nalidixic acid to 26.7% for sulfamethoxazole. For Roermond (n=670) the figures varied from 0.6% for nitrofurantoin to 37.5% for sulfamethoxazole. Resistance to amoxicillin/clavulanate was not found in either city. The most frequent pattern was resistance to sulfamethoxazole only, followed by resistance to oxytetracycline, streptomycin and sulfamethoxazole. In each individual there was only a small variation in resistance patterns of the isolates, i. e. the majority had one (n=51) or two (n=63) patterns with a maximum of five during the 15-week period. A fully susceptible pattern was found in the strains from 38 individuals.

Zusammenfassung

Stämme vonEscherichia coli, (n=678 und n=670), die aus Stuhlproben von jeweils 90 und 93 gesunden Freiwilligen aus zwei Städten, Weert und Roermond, gewonnen wurden, wurden auf ihre Empfindlichkeit gegenüber 12 antimikrobiellen Substanzen geprüft. Die Untersuchung lief über 15 Wochen. Für Apramycin, Chloramphenicol, Kanamycin, Neomycin, Nitrofurantoin, Sulfamethoxazol und Trimethoprim fanden sich zwischen den beiden Städten signifikante Unterschiede in den MHK-Werten. Für Weert (n=678) fanden sich Resistenzraten, die von 0,4% bei Nalidixinsäure bis 26,7% für Sulfamethoxazol reichten. In Roermond (n=670) variierten die Resistenzraten von 0,6% für Nitrofurantoin bis 37,5% für Sulfamethoxazol. In keiner der beiden Städte fand sich Resistenz gegenüber Amoxicillin-Clavulansäure. Als häufigstes Muster fand sich Resistenz gegen Sulfamethoxazol allein, es folgten Resistenz gegen Oxytetracyklin, Streptomycin und Sulfamethoxazol. Die intraindividuellen Resistenzmuster der Isolate variierten nur sehr wenig, das heißt, die meisten hatten Resistenz gegen ein (n=51) oder zwei (n=63) Antibiotika, maximal fünf während der 15 Wochen. Bei 38 Personen zeigten alle Stämme volle Empfindlichkeit gegen die Testsubstanzen.

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Authors and Affiliations

  1. Dept. of Medical Microbiology, University of Limburg, P. O. Box 5800, NL-6202 AZ, Maastricht, The Netherlands

    Nancy London B. Sc., R. Nijsten DVM, A. v. d. Bogaard DVM &  E. Stobberingh Ph. D.

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  1. Nancy London B. Sc.
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  3. A. v. d. Bogaard DVM
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London, N., Nijsten, R., Bogaard, A.v.d. et al. Carriage of antibiotic-resistantEscherichia coli by healthy volunteers during a 15-week period. Infection 22, 187–192 (1994). https://doi.org/10.1007/BF01716700

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