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Neopterin im Serum und Urin zur Differentialdiagnose von Nierenfunktionsstörungen nach Nierentransplantation

Neopterin in serum and urine for the differential diagnosis of renal dysfunction in kidney allograft recipients

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Summary

In a period of 10 months neopterin in serum and urine was determined by radioimmunoassay in 33 renal allograft recipients treated with cyclosporin A. While in allograft rejections the highest neopterin concentrations were found in the serum, patients with viral infections after renal transplantation showed the most elevated concentrations in the urine. For early diagnosis of allograft rejection the ratio of neopterin clearance and serum-neopterin was the most significant criterion of the parameters measured in this study. Patients without complications during the follow-up showed slightly elevated and stable neopterin levels in serum and urine. The presented results indicate that neopterin is a useful parameter for the follow-up after renal allograft transplantation and for the diagnosis of immunological complications.

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Abbreviations

CyA:

Cyclosporin A

Kr-Cl:

Kreatinin-Clearance

NPT-Cl:

Neopterin-Clearance

sKr:

Kreatinin im Serum

sNPT:

Neopterin im Serum

uNPT:

Neopterin im Urin

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Authors and Affiliations

  1. Medizinische Universitätsklinik Bonn-Venusberg, Germany

    J. Wolf, E. Musch, H. Neuss & U. Klehr

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  1. J. Wolf
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  2. E. Musch
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  3. H. Neuss
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  4. U. Klehr
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Wolf, J., Musch, E., Neuss, H. et al. Neopterin im Serum und Urin zur Differentialdiagnose von Nierenfunktionsstörungen nach Nierentransplantation. Klin Wochenschr 65, 225–231 (1987). https://doi.org/10.1007/BF01715851

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  • DOI: https://doi.org/10.1007/BF01715851

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