Summary
In vitro investigations have shown that the adsorption capacity of activated charcoal (‘Kohle-Compretten’, ‘Ultracarbon’, E. Merck, Darmstadt, FRG) is just as high as that of ‘Fuller's earth’ (Surrey powder, Laporte Industries Ltd., Luton, GB) or ‘Bentonite BP W.B.’ (Steetley Minerals Ltd., Milton Keynes, GB). Fuller's earth (‘Fullererde’) from another manufacturer has had very poor adsorption properties and is thus not suitable for the treatment of paraquat poisoning. Animal experiments have shown that the curative effect of activated charcoal given 0.5, 1, 2, and 3 h after ingestion of 200 and 300 mg paraquat/kg body weight is equally as good or even better than that of ‘Fuller's earth’ or ‘Bentonite BP W.B.’. Activated charcoal is a substitute of equal value to these mineral soils.
Zusammenfassung
In vitro-Untersuchungen haben ergeben, daß die Adsorptionskapazität von Aktivkohle (‘Kohle-Compretten’, ‘Ultracarbon’, E. Merck, Darmstadt, FRG), ebenso groß ist, wie diejenige von ‘Fuller's Earth’ (Surrey powder, Laporte Ind. Ltd., Luton, GB) und ‘Bentonit BP W.B.’ (Steetly Minerals Ltd., Milton Keynes, GB). ‘Fullererde’ einer anderen Firma hatte so geringe Adsorptionsfähigkeit, daß sie zur Behandlung der Paraquat-Vergiftung nicht geeignet ist. In Tierversuchen konnte gezeigt werden, daß der kurative Effekt von Aktivkohle, die 0,5, 1, 2 und 3 Stunden nach der Ingestion von 200 bzw. 300 mg Paraquat pro kg Körpergewicht verabfolgt wurde, ebenso gut oder sogar besser ist, als diejenige von ‘Fuller's Earth’ oder ‘Bentonit BP W.B.’. Aktivkohle ist ein gleichwertiger Ersatz der Mineralerden.
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Okonek, S., Setyadharma, H., Borchert, A. et al. Activated charcoal is as effective as fuller's earth or bentonite in paraquat poisoning. Klin Wochenschr 60, 207–210 (1982). https://doi.org/10.1007/BF01715588
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DOI: https://doi.org/10.1007/BF01715588