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Blood pressure in essential hypertension correlates with the concentration of a circulating inhibitor of the sodium pump

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Summary

The influence of serum from patients with essential hypertension on the sodium efflux rate constants of human lymphocytes and on the activity of isolated (Na++K+)-ATPase was investigated. The ouabain-sensitive sodium efflux rate constant was significantly decreased (p<0.001) in the sera of 19 hypertensives (1.92±0.11 h−1) compared with the sera of 30 normotensives (2.44±0.07 h−1). The ouabain-insensitive sodium efflux was unaffected. These results corresponded with a significant difference (p<0.005) of (Na++K+)-ATPase activity (1.03±0.04 mU/ml and 0.079±0.06 mU/ml), when an isolated (Na++K+)-ATPase was incubated with the sera of 22 normotensives or 18 hypertensives. Both the rate constant of ouabain-sensitive sodium efflux and the (Na++K+)-ATPase activity correlated significantly with the diastolic and systolic blood pressure (p<0.001). These data, therefore, demonstrated the close relationship between essential hypertension and the concentration of a circulating inhibitor of the sodium pump.

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Abbreviations

ATP:

Adenosine triphosphate

EGTA:

Ethyleneglycol bis(2-aminoethyl)-N,N,N′,N′-tetraacetic acid

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Authors and Affiliations

  1. Institut für Biochemie und Endokrinologie, Fachbereich Veterinärmedizin, Justus-Liebig-Universität Giessen, Germany

    K. Moreth, R. Kuske & W. Schoner

  2. II. Medizinische Klinik, Krankenhauszweckverband Augsburg, Germany

    D. Renner

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  1. K. Moreth
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  2. R. Kuske
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  3. D. Renner
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  4. W. Schoner
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Additional information

This paper contains an essential part of the thesis of K.M. presented to the Fachbereich Veterinärmedizin, Giessen

This work was supported by the Deutsche Forschungsgemeinschaft, Bonn-Bad Godesberg (Scho 139/16-2) and by the Fonds der Chemischen Industrie, Frankfurt/Main

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Moreth, K., Kuske, R., Renner, D. et al. Blood pressure in essential hypertension correlates with the concentration of a circulating inhibitor of the sodium pump. Klin Wochenschr 64, 239–244 (1986). https://doi.org/10.1007/BF01711656

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  • DOI: https://doi.org/10.1007/BF01711656

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