Skip to main content
Log in

The effect of sedation with propofol on postoperative bronchoconstriction in patients with hyperreactive airway disease

  • Case reports
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

Abstract

Two patients with chronic obstructive pulmonary disease developed postoperatively bronchospasm after insertion of a prostetic aortic valve. Continuous sedation with propofol infusion was associated with a significant decline in peak inspiratory pressure suggesting that propofol may have bronchodilating properties.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. McCollum JSC, Dundee JW (1986) Comparison on induction characteristics of four intravenous agents. Anaesthesia 41: 995–1000

    Google Scholar 

  2. Kanto J, Gepts E (1989) Pharmacokinetic implications for the clinical use of propofol. Clin Pharmacokinet 17:308–326

    Google Scholar 

  3. Aitkenhead AR, Pepperman ML, Willatts SM, Coates PD, Park GR, Bodenham AR, Collins CH et al (1989) Comparison of propofol and midazolam for sedation in critically ill patients. Lancet II:704–708

    Google Scholar 

  4. McMurray TJ, Collier PS, Carson IW, Lyons SM, Elliott P (1990) Propofol sedation after open heart surgery. A clinical and pharmacokinetic study. Anaesthesia 45:322–326

    Google Scholar 

  5. Schwartz SH (1984) Treatment of status asthmaticus with halothane. JAMA 251:2688–2689

    Google Scholar 

  6. Rock MJ, De la Rocha SR, L'Hommedieu CS, Truemper E (1986) Use of ketamine in asthmatic children to treat respiratory failure refractory to conventional therapy. Crit Care Med 14:514–516

    Google Scholar 

  7. Cullen PM, Turtle M, Prys-Roberts C, Way WL, Dye J (1987) Effect of propofol anesthesia on baroreflex activity in humans. Anesth Analg 66:1115–1120

    Google Scholar 

  8. Bentley GN, Gent JP, Goodchild CS (1989) Vascular effects of propofol: smooth muscle relaxation in isolated veins and arteries. J Pharm Pharmacol 41:797–798

    Google Scholar 

  9. Bunting P, Ramsay TM, Pleuvry BJ (1989) An in-vitro study of the interactions between intravenous induction agents and the calcium antagonists verapamil and nifedipine. J Pharm Pharmacol 41:840–843

    Google Scholar 

  10. Eriksson O (1991) Effects of the general anaesthetic propofol on the Ca2+-induced permeabilization of rat liver mitochondria. FEBS Lett 279:45–48

    Google Scholar 

  11. Gigarini I, Bonnet F, Lorino AM, Harf A, Desmonts JM (1990) Comparison of the effects of fentanyl on respiratory mechanics under propofol or thiopental anaesthesia. Acta Anaesth Scand 34:253–256

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pedersen, C.M. The effect of sedation with propofol on postoperative bronchoconstriction in patients with hyperreactive airway disease. Intensive Care Med 18, 45–46 (1992). https://doi.org/10.1007/BF01706426

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01706426

Key Words

Navigation