Abstract
The full-length cDNA of a new Chinese strain (KS2-87) of Hepatitis E virus (HEV) has been constructed and sequenced. The 5′ noncoding region of KS2-87 is 26 nucleotides in length, which is one nucleotide shorter than that of HEV (B1) (Burma) and 23 nucleotides longer than that of HEV (Mexico). Comparison of the nucleotide and amino acid sequences of KS2-87 with all other published HEV sequences showed that KS2-87 was closer to two other Chinese strains (CHT-88, CHT-87) and SAR-55 (Pakistan) than to HEV (B1) and HEV (B2) (Burma) or HEV (Mexico). Comparisons of partial sequences of genes encoding a nonstructural and a structural protein revealed the existence of genetically related groups of HEV within geographical regions, whereas larger nucleotide differences were seen among isolates that were more geographically and epidemiologically distant.
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Gust I.D. and Purcell R.H., J Infect Dis156 630–635, 1987.
Purcell R.H., and Ticehurst J.R. in Zuckerman A.J. (ed)Viral Hepatitis and Liver Disease. Alan R. Liss, New York, 1988, pp. 131–137.
De cock K.M., Bradley D.W., Sandford N.L., Govindarajan S., Maynard J.E., and Redeker A.G., Ann Intern Med106 227–230, 1987.
Bradley D.W., Krawczynski K., Cook, Jr. E.H., McCaustland K.A., Humphrey C.D., Spelbring J.E., Myint H., and Maynard J.E., Proc Natl Acad Sci USA84 6277–6281, 1987.
Panda S.K., Datta R., Kaur J., Zuckerman A.J., and Nayak N.C., Hepatology10 466–472, 1989.
Reyes G.R., Purdy M.A., Kim J., Luk K.-C., Young L.M., Fry K.E., and Bradley D.W., Science247 1335–1339, 1990.
Tam A.W., Smith M.M., Guerra M.E., Huang C.C., Bradley D.W., Fry K.E., and Reyes G.R., Virology185 120–131, 1991.
Yarbough P.O., Tam A.W., Fry K.E., Krawczynski K., McCaustland K.A., Bradley D.W., and Reynes G.R., J Virol65 5790–5797, 1991.
Tsarev S.A., Emerson S.U., Reyes G.R., Tsareva T.S., Legters L.J., Malik I.A., Iqbal M., and Purcell R.H., Proc Natl Acad Sci USA89 559–563, 1992.
Ticehurst J., Popkin T.J., Bryan J.P., Innis B.L., Duncan J.F., Ahmed A., Iqbal M. Malik I., Kapikian A.Z., Legters L.J., and Purcell R.H., J Med Virol36 84–92, 1992.
Huang C.-C., Nguyen D., Fernandez J., Yun K.Y., Fry K.E., Bradley D.W., Tam A.W., and Reyes G.R., Virology191 550–558, 1992.
Bradley D.W., Andjaparidze A.G., Cook Jr. E.H., McCaustland K.A., Balayan M., Stetler H., Velazquez O., Robertson B., Humphrey C.D., Kane M., and Weisfuse I., J Gen Virol69 731–738, 1988.
Aye T.T., Uchida T., Ma X., Iida F., Shikata T., Ichikawa M., Rikihisa T., and Win K.M., Virus Genes7 95–110, 1993.
Uchida T., Win K.M., Suzuki K., Komatsu K., Iida F., Shikata T., Rikihisa T., Mizuno K., Soe S., Myint H., Tin K.M., and Nakane K., Jpn J Exp Med60 13–21, 1990.
Aye T.T., Uchida T., Ma X.Z., Iida F., Shikata T., Zhuang H., and Win K.M., Nucleic Acids Res20 3512–3512, 1992.
Bi S.L., Purdy M.A., McCaustland K.A., Margolis H.S., and Bradley D.W., Virus Res28 233–247, 1993.
Yin S.R., Tsarev S.A., Purcell R.H., and Emerson S.U., J Med Virol41 230–241, 1993.
Kramer G. and Argos P., Nucleic Acids Res12 7269–7282, 1984.
Gorbalenya A.E., Koonin E.V., Donchenko A.P., and Blinov V.M., Nucleic Acids Res17 4713–4730, 1989.
Rice C.M., Lenches E.M., Eddy S.R., Shin S.J., Sheets R.L., and Strauss J.H., Science229 726–733, 1985.
Ray R., Jameel S., Manivel V., and Ray R., Virology189 359–362, 1992.
Reyes G.R., Huang C.-C. Yarbough P.O., and Tam A.W., Hepatology13 S155-S161, 1991.
Cao X.Y., Ma X.Z., Liu Y.Z., Jin X.M., Gao Q., Dong H.J., Zhuang H, Liu C.B., and Wang G.M. in Shikata T., Purcell R.H., and Uchida T. (eds).Viral Hepatitis C, D and E. Elsevier Science Publishers, Amsterdam, The Netherlands, 1991, pp. 275–285.
Zhuang H., Cao X.Y., Liu C.B., and Wang G.M., in Shikata T., Purcell R.H., and Uchida T. (eds).Viral Hepatitis C, D and E. Elsevier Science Publishers, Amsterdam, The Netherlands, 1991, pp. 275–285.
Rico-Hesse R., Pallansch M.A., Nottay B.K., and Kew O.W., Virology160 311–322, 1987.
Jarvis T.C. and Kirkegaard K., EMBO J11 3135–3145, 1992.
Kazachkov Y.A., Balayan M.S., Ivannikova T.A., Panina L.I., Orlova T.M., Zamyatina N.A., and Kusov Y.Y. Arch Virol127 399–402, 1992.
Emerson S.U., Lewis M., Govindarajan S., Shapiro M., Moskal T., and Purcell R.H. J Virol66 6649–6654, 1992.
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Yin, S., Purcell, R.H. & Emerson, S.U. A new Chinese isolate of Hepatitis E virus: Comparison with strains recovered from different geographical regions. Virus Genes 9, 23–32 (1994). https://doi.org/10.1007/BF01703432
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DOI: https://doi.org/10.1007/BF01703432