Abstract
The published studies on immunization of experimental animals, cattle, and sheep with synthetic peptides containing the antigenic domains in FMDV structural protein VP1 were analyzed. The results obtained with various FMDV synthetic peptides designed to stimulate the humoral immune response in bovines were compared to the current knowledge on MHC class I and class II, and the properties of the peptide binding grooves in each of them. X-ray crystallography of MHC class I proteins provided the three-dimensional structure of the peptide binding groove and led to the isolation and identification of “self” and viral peptides that naturally associate with the peptide binding grooves of both types of MHC and HLA molecules. The available knowledge of the amino acid motifs in MHC and HLA class I-bound viral peptides priming the CD8+ cytotoxic T cell responses must be coupled with the understanding of the three-dimensional structure of BoLA class I. This would aid in the development of an experimental approach to induce bovine anti-FMDV CD8+ cytotoxic cells to complement the humoral immune response to FMDV, which is currently achieved by a killed virus vaccine and, at the experimental level, by a peptide vaccine. Stimulation of both cellular and humoral immune responses against FMDV in cattle may reduce the risk of disease and virus shedding.
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Acharya R., Fry E., Stuart D., Fox G., Rowlands D., and Brown F., Nature337 709–716, 1989.
Brown, F., Vaccine6 180–182, 1988.
Brown F., World J Microb Biotech7 110–114, 1990.
Brown F., Vaccine10 1022–1026, 1992.
Kaaden O.R., Adam K.H., and Strohmaier K. J Gen Virol34 397–400, 1977.
Strohmaier K., Franz R., and Adam K.H., J Gen Virol59 295–306, 1982.
Anderer F.A., Naturforsch Teil B,188 1010, 1963.
Langebebeheim H., Arnon R., and Sela M., Proc Natl Acad Sci USA73 4636–4640, 1976.
Bittle J.L., Houghton R.A., Alexander H., Shinnick T.M., Sutcliffe J.G., Lerner R.A., Rowlands D.J., and Brown F., Nature298 30–33, 1982.
Pfaff E., Mussgay M., Bohm H.O., Schulz G.E., and Schaller H., EMBO J7 869–874, 1982.
Townsend, A.R.M. and Bodmer H., Ann Rev Immunol7 601–624, 1989.
Townsend, A.R.M., Rothbert J., Gotch, F.M., Bahadur G., Wraith D., and McMichael A.J., Cell44 959–967, 1986.
Townsend, A.R.M. and Shekel J.J., J Exp Med160 552–563, 1984.
Townsend, A.R.M. and Shekel J.J., Nature300 655–657, 1982.
Townsend, A.R.M., Immunol Res6 80–100, 1987.
Bjorkman, P.J., Saper M.A., Samaraoui B., Bennett W.S., Strominger J.L., and Wiley D.C., Nature329 506–512, 1987.
Bjorkman P.J., Saper M.A., Samaraoui B., Bennett W.S., Strominger J.L., and Wiley D.C., Nature329 512–518, 1987.
Falk K., Rotzschke O., Stevanovic S., Jung G., and Ransmensee H.G., Nature351 290–296, 1991.
Jaredetsky T.S., Lane W.S., Robinson R.A., Maden D.R., and Wiley D.C., Nature353 326–329, 1991.
Allen P.M., Matsueda G.R., Evans R.J., Dunbar J.B., Marshall G.R., and Unanue E.R., Nature327 713–715, 1987.
Rudensky A.Y., Preston-Hurlburt P., Al-Ramadi B.K., Rothbard J., and Janeway C.A. Jr., Nature359 429–431, 1992.
Shimonkewitz R., Kappler J., Marrock P., and Grey H., J Exp Med158 303–316, 1983.
Silver M.L., Guo H-C., Strominger J.L., and Wiley D.C., Nature360 367–369, 1992.
Bjorkman P.J. and Parham P., Ann Rev Biochem59 253–288, 1990.
Austyn J.M., Semin Immunol4 227–236, 1992.
Doel T.R., Vaccine3 35–36, 1985.
Glass E.J., Oliver R.A., Collen T., Doel T.R., Dimarchi R., and Spooner R., Immunology74 594–599, 1991.
Ennis P.D., Jackson A.P., and Parham P., J Immunol141 642–651, 1988.
Burke M.G., Stone R.T., and Muggli-Cockett N.E., Anim Genet22 343–352, 1991.
Joosten I., Teale A.J., van der Poel A., and Hensen E.J., Anim Genet23 113–123, 1992.
Zinkernagel R.M. and Doherty P.C., Nature248 701–702, 1974.
Oldstone M.B.A., J Virol65 6381–6386, 1991.
Francis M.J., Fry C.M., Rowlands D.J., Brown F., Bittle J.L., Houghton R.A., and Lerner R.A., J Gen Virol66 2347–2354, 1985.
Francis J.M., Fry C.M., Rowlands D.J., and Brown F.J., Gen Virol69 2483–2491, 1988.
Meloen R.H., Puyk W.C., Meijer D.J.A., Lankhof H., Posthumus W.P.H., and Schaaper W.M.M., J Gen Virol68 305–314, 1987.
Geysen H.M., Bartling S., and Meloen R.H., Proc Natl Acad Sci USA82 178–182, 1985.
Surovoy A.Y., Snetkova V.O.M., Volkova T.B., Ivanov V.T., Chepurkin A.V., Ivanynshchenkov V.N., Burdov A.N., and Dryagalin N.N., Bioorg Khim14 1352–1362, 1988.
Volpina O.M., Surovoy A.Y., Ulyashin V.V., Ivanov V.T., Chapurkin A.V., Ivanynshchenkov V.M., Burdov A.N., and Dryagalin N.N., Bioorg Khim14 1363–1371, 1988.
Doel T.R., Gale C., Brooke G., and Dimarchi R., J Gen Virol69 2403–2406, 1988.
Francis M.J., Hastings G.Z., Brown F., McDermed J., Lu Y.-A., and Tam J.P., Immunology73 249–254, 1991.
Doel T.R., Gale C., Do Amraal C.M.C.F., Mulcahy G., and Dimarchi R., J Virol64 2260–2264, 1990.
Cox J.H., Ivanyi J., Young D.B., Lamb J.R., Syred A.D., and Francis M.J., Eur J Immunol18 2015–2019, 1988.
Francis M.J., Hastings G.Z., Syred A.D., McGinn B., Brown F., and Rowlands D.J., Nature300 168–170, 1987.
Xie Q.-C., McMahon D., Crowther J.R., Belsham G.J., and McCullough K.C., J Gen Virol68 1637–1647, 1987.
Parry N.R., Barnett P.V., Oikdridge E.J., Rowlands D.J., and Brown F., J Gen Virol70 1493–1503, 1989.
Dimarchi R., Brooke G., Gale C., Cracknell V., Doel T., and Mowat N., Science232 639–641, 1986.
Steward M.W., Stanley C.M., Dimarchi R., Mulcahy G., and Doel T.R., Immunology72 99–103, 1991.
Mulcahy G., Reid E., Dimarchi R.D., Gale C., and Doel T.R., Res Vet Sci52 133–140, 1992.
Flynn J.N., Harkiss G.D., Doel T., and Dimarchi R., Immunology69 1–7, 1990.
Collen T., Dimarchi R., and Doel T.R., J Immunol146 749–755, 1991.
Collen T. and Doel T.R., J Gen Virol71 309–315, 1990.
Flynn J.N., Harkiss G.D., Moore D., and Dimarchi T., Vet Immunol Immunopathol31 255–266, 1992.
Brown J.H., Jardetsky T.S., Gorga J.C., Stern L.J., Urban R.G., Strominger J.L., and Wiley D.C., Nature364 33–39, 1993.
Hunt D., Michel H., Dickinson T.A., Shabonowitz J., Cox A.L., Sakaguchi K., Apella E., Grey H.M., and Sette A., Science256 1817–1820, 1992.
Barclay A.N., Birkeland M.L., Brown M.H., Beyers A.D., Lomoza C., and Williams A.F., inThe Leucocyte Antigen Facts Book, Harcourt Brace Jovanovich Publishers, London, San Diego, New York, Boston, Sydney, Tokyo, Toronto, 1993, pp. 376–377.
Riberdy J.M., Newcomb J.R., Surman M.J., Barbosa J.A., and Crosswell P., Nature360 474–477, 1992.
Budensky A.Y., Preston-Hurlburt P., Hong S-C., Barlow A., and Janeway C.A., Jr., Nature353 622–627, 1991.
Saper M.A., Bjorkman P.J., and Wiley D.C., J Mol Biol219 277–319, 1991.
Guo H-C., Jardetsky T.S., Garrett T.P., Lane W.S., Strominger J.L., and Wiley D.C., Nature360 364–366, 1992.
Ljunggren G-G., Stam N.J., Ohlen C., Neefjes, J.J., Häglumd P., Heemels M-T., Bastin J., Schumacher T.N.M., Townsend H., Kärre K., and Ploegh H.L., Nature436 476–480, 1990.
Schumacher T.N.M., De Bruijn M.L.H., Vernie L.N., Kast W.M., Melief L.J.M., Neefjes J.J., and Ploegh H.L., Nature350 703–706, 1991.
Gotch F., Rothbard J., Howland K., Townsend A., and McMichael A., Nature326 881–882, 1987.
Bond J.S., and Butler P.E., Ann Rev Biochem56 333–364, 1987.
Powis S.J., Townsend A.R.M., Deverson E.V., Bastin J., Butcher G.W., and Howard J.C., Nature354 528–531, 1991.
Spies T., Bresnahan M., Bahram S., Arnold D., Blanck G., Melliis E., Pious D., and DeMars R., Nature348 744–747, 1990.
Parker K.C., DiBrino M., Hull L., and Coligan J.E., J Immunol149 1896–1904, 1992.
Brodsky M.F., Stone W.H., and Parham P., Hum Immunol3 143–152, 1981.
Iha T.H., Gerbrandt G., Bodmer W.F., McGary D., and Stone W.H., Tissue Antigens3 291–302, 1973.
Bernoco D., Lewin H.A., Andersson L., Arrienns, M.A., Byrns G., Cwik S., Davies C.J., Hines H.C., Leibold W., Lie O., et al., Anim Genet22 477–496, 1991.
Davies C.J., Andersson L., Joosten I., Mariani P., Gasbarre L.C., and Hensen E.J., Eur J Immunogen19 253–262, 1992.
van der Poel J.J., Groenen M.A., Dijkhof R.J., Ruyter D., and Giphart M.J., Immunogenetics31 29–36, 1990.
Groenen M.A., van der Poel J.J., Dijkhof R.J., and Giphart M.J., Immunogenetics31 37–44, 1990.
Xu A., Clark T.J., Teutsch M.R., Schook L.B., and Lewin H.A., Anim Genet22 381–398, 1991.
Burke M.G., Stone R.T., and Muggli-Cockett N.E., Anim Genet22 343–352, 1991.
Lunden A., Sigurdardottir S., Edfors Lilja I., Danell B., Rendel J., and Andersson L., Anim Genet21 221–232, 1990.
Brown, P., Spooner R.L., and Clark A.J., Immunogenetics29 58–60, 1989.
Ben-Said A., Kaushal A., Baldwin C.L., Clevers H., Young J.R., Kemp S.J., Stall D., MacHugh A.D., Toye P.G., and Teale A.J., Immunogenetics33, 247–254.
Garber T.L., Hughes A.L., Letvin N.L., Templeton J.W., and Watkins D.I., Immunogenetics38 11–20, 1993.
Grossberger, D., Hein W., and Marcus A., Immunogenetics32 77–78, 1990.
Amadori M., Archetti I.L., Verardi R., and Berneri C., Vet Microbiol33 383–392, 1992.
Amadori M., Archetti I.L., Verardi R., and Berneri C., Arch Virol122 293–306, 1992.
McKinney E.C. and Streilein J.W., J Immunol143, 1560–1564, 1989.
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Becker, Y. Need for cellular and humoral immune responses in bovines to ensure protection from foot-and-mouth disease virus (FMDV)—A point of view. Virus Genes 8, 199–214 (1994). https://doi.org/10.1007/BF01703078
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DOI: https://doi.org/10.1007/BF01703078