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Pneumococcal community-acquired pneumonia in 148 hospitalized adult patients

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Abstract

In a previous prospective study,Streptococcus pneumoniae was identified as the causative agent in 148 (42.8%) of 346 adult patients hospitalized over the course of one year with community-acquired pneumonia (CAP) in the Soroka Medical Center, Beer-Sheva, Israel. The present study characterizes those cases in whichStreptococcus pneumoniae was the only pathogen and those in which additional etiological agents were identified. Pneumococcal CAP was diagnosed by standard blood cultures or positive serological tests by one of two laboratory methods. In 100 (67.6%) patients, at least one other etiological agent of CAP was identified in addition toStreptococcus pneumoniae. Compared with patients who were not infected byStreptococcus pneumoniae, patients withStreptococcus pneumoniae CAP were older and had a higher rate of comorbidity (39.5% vs. 29.8%).Streptococcus pneumoniae CAP had a more severe clinical course and a higher mortality rate, especially whenStreptococcus pneumoniae was the only pathogen. Community-acquired pneumonia due toStreptococcus pneumoniae only was more similar in its clinical manifestations to classic typical pneumococcal pneumonia. When an additional etiological agent was identified, the clinical characteristics could not be distinguished from those of atypical pneumonia. It is concluded thatStreptococcus pneumoniae remains the principal cause of CAP in this region. The frequency of additional etiological agents of CAP and the difficulty in differentiating clinically between cases due toStreptococcus pneumoniae only and those due toStreptococcus pneumoniae plus other organisms necessitates initial empirical treatment that coversStreptococcus pneumoniae as well as other causative agents of atypical pneumonia.

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Authors and Affiliations

  1. Division of Internal Medicine, Department of Medicine F, Soroka Medical Center of Kupat Holim, 84101, Beer-Sheva, Israel

    A. Porath, F. Schlaeffer, N. Pick & D. Lieberman

  2. Faculty of the Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

    A. Porath, F. Schlaeffer, N. Pick & D. Lieberman

  3. The National Public Health Institute, Oulu, Finland

    M. Leinonen

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  1. A. Porath
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  2. F. Schlaeffer
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  4. M. Leinonen
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  5. D. Lieberman
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Porath, A., Schlaeffer, F., Pick, N. et al. Pneumococcal community-acquired pneumonia in 148 hospitalized adult patients. Eur. J. Clin. Microbiol. Infect. Dis. 16, 863–870 (1997). https://doi.org/10.1007/BF01700551

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