Skip to main content
SpringerLink
Log in

Nierenbefall bei angioimmunoblastischer Lymphadenopathie mit hochgradiger Insuffizienz — Remission nach hochdosierter Corticoidgabe

Ein Fallbericht

Disease-specific renal failure in angioimmunoblastic lymphadenopathy — Remission by high dose prednisolone

A case report

  • Originalien
  • Published:
Klinische Wochenschrift Aims and scope Submit manuscript

Summary

The case of a 64 years old male with angioimmunoblastic lymphadenopathy (AIL) is reported, who developed disease specific infiltration of the kidneys with progressive destruction of renal parenchyma leading to high grade renal insufficiency. This unusual organ manifestation of AIL has not been previously reported. By treatment with high dose prednisolone and intense supportive therapy the patient underwent complete remission of AIL with preservation of the remaining renal function. Clinical, laboratory and immunological data are given as well as a light and electron microscopic evaluation of the renal involvement.

Zusammenfassung

Ein Fall eines 64 Jahre alten Patienten mit Angioimmunoblastischer Lymphadenopathie (AIL) wird berichtet, in dem es zu einer ungewöhnlichen, bisher nicht beschriebenen Organmanifestation in Form einer Infiltration der Nieren mit progressiver Zerstörung des Parenchyms und hochgradiger Insuffizienz kam. Unter hochdosierter Prednisolongabe sowie intensiver unterstützender Therapie wurde eine Vollremission der AIL erzielt und die Nierenrestfunktion erhalten. Klinische, Labor- und immunologische Daten sowie licht- und elektronenoptische Befunde werden berichtet.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  1. Andrieu JM, Youinou P, Herzog C (1979) Levamisole and autoimmunity in angioimmunoblastic lymphadenopathy. Acta Haematol 62:117–118

    PubMed  Google Scholar 

  2. Bluming AZ, Cohen HG, Saxon A (1979) Angioimmunoblastic lymphadenopathy with dysproteinaemia. Am J Med 67:421–428

    PubMed  Google Scholar 

  3. Deeg HJ, Singer JW, Huang ThW (1979) Angioimmunoblastic lymphadenopathy with retinitis and drug related exacerbations. Cancer 44:1745–1750

    PubMed  Google Scholar 

  4. Donhuijsen K, Leder LD (1979) Zur Natur, Prognose und Nomenklatur der angioimmunoblastischen Lymphadenopathie (Lymphogranulomatosis X bzw. T-Zonen-Lymphom). Dtsch Med Wochenschr 104:887–888

    PubMed  Google Scholar 

  5. Fisher RI, Jaffe ES, Braylan RC, Anderson JD, Tan HK (1976) Immunoblastic lymphadenopathy — evolution into a malignant lymphoma with plasmacytoid features. Am J Med 6:553–559

    Google Scholar 

  6. Frizzera G, Moran EM, Rappaport H (1975) Angio-immunoblastic lymphadenopathy. Am J Med 59:803–818

    PubMed  Google Scholar 

  7. Frizzera G, Moran EM, Rappaport H (1974) Angio-immunoblastic lymphadenopathy with dysproteinaemia. Lancet 1:1070–1073

    PubMed  Google Scholar 

  8. Graham RC (1974) Pathogenesis of vascular proliferation in angio-immunoblastic lymphadenopathy with dysproteinaemia. Lancet 2:666

    Google Scholar 

  9. Kreisler JM, Moreno E, Moneo J, Bootello A, Bouza E, Martinez de Letona J, Anaya A (1977) Immunological findings in immunoblastic lymphadenopathy. Clin Exp Immunol 27:497–501

    PubMed  Google Scholar 

  10. Leder LD, Donhuijsen K (1978) PAS-positive lymphatic cells in angioimmunoblastic lymphadenopathy. Klin Wochenschr 56:225–227

    PubMed  Google Scholar 

  11. Lennert K (1978) Malignant lymphomas other than Hodgkin's disease. In: Handbuch der speziellen pathologischen Anatomie und Histologie, Bd. I/3. Springer, Berlin Heidelberg New York

    Google Scholar 

  12. Lukes RJ, Tindle BH (1975) Immunoblastic lymphadenopathy. A hyperimmune entity resembling Hodgkin's disease. N Engl J Med 292:1–8

    PubMed  Google Scholar 

  13. Lukes JR, Collins RD (1974) Immunologic characterization of human malignant lymphomas. Cancer 34:1488–1503

    PubMed  Google Scholar 

  14. Matz LR, Papadimitriou JM, Carroll JR, Barr AL, Dawkins RL, Jackson JM, Herrmann RP, Armstrong BK (1977) Angioimmunoblastic lymphadenopathy with dysproteinaemia. Cancer 40:2152–2160

    PubMed  Google Scholar 

  15. Nathwani BN, Rappaport H, Moran EM, Pangalis GA, Kim H (1978) Malignant lymphoma arising in angio-immunoblastic lymphadenopathy. Cancer 41:578

    PubMed  Google Scholar 

  16. Neiman RS, Dervan P, Haudenschild C, Jaffe R (1978) Angioimmunoblastic lymphadenopathy. Cancer 41:507–518

    PubMed  Google Scholar 

  17. Pangalis GA, Moran EM, Rappaport H (1978) Blood and bone marrow findings in angioimmunoblastic lymphadenopathy. Blood 51:71–83

    PubMed  Google Scholar 

  18. Pruzansky W, Sutton DMC, Pantalony D (1976) Angioimmunoblastic lymphadenopathy: An immunochemical study. Clin Imm Immunopathol 6:62–76

    Google Scholar 

  19. Radaszkiewicz T, Lennert K (1975) Lymphogranulomatosis X. Dtsch Med Wochenschr 100:1157–1163

    PubMed  Google Scholar 

  20. Rappaport H, Moran EM (1975) Angio-immunoblastic (immunoblastic) lymphadenopathy. N Engl J Med 292:42–43

    PubMed  Google Scholar 

  21. Reynaud R, Emberger JM, Ciurana AJ, Blanc F, Bertrand L (1978) La lympho-adénopathie angioimmunoblastique. Schweiz Med Wochenschr 108:325–331

    PubMed  Google Scholar 

  22. Schmidt CG (1978) Angio-immunoblastische Lymphadenopathie. Dtsch Med Wochenschr 103:1504

    Google Scholar 

  23. Schoengen A, Feyen H, Haferkamp O, Heimpel H, Kubanck B (1977) Immunoblastische Lymphadenopathie — maligne Neoplasie oder hyperimmunisatorische Reaktion? Klin Wochenschr 55:265–273

    PubMed  Google Scholar 

  24. Sidky Y, Auerbach R (1975) Lymphocyte induced angiogenesis: A quantitative and sensitive assay of the Graft-versus-host-reaction. J Exp Med 141:1084–1100

    PubMed  Google Scholar 

  25. Spector JI, Miller S (1977) Immunoblastic lymphadenopathy. JAMA 238:1263–1265

    PubMed  Google Scholar 

  26. Vohra RM, Patel AR, Khandeparker RV et al. (1977) Immunoblastic lymphadenopathy with upper respiratory obstruction. Ann Int Med 86:830–838

    Google Scholar 

  27. Weisenburger D, Armitage J, Dick F (1977) Immunoblastic lymphadenopathy with pulmonary infiltrates, hypocomplementemia and vasculitis. Am J Med 63:849–854

    PubMed  Google Scholar 

  28. Wood WG, Harkins MM (1979) Nephropathy in angioimmunoblastic lymphadenopathy. Am J Clin Pathol 71:58–63

    PubMed  Google Scholar 

  29. Zylak CJ, Banerjee R, Galbraith PA, McCarthy DS (1976) Lung involvement in angioimmunoblastic lymphadenopathy. Radiology 121:513–519

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für klinische Immunologie der Universität Erlangen-Nürnberg, Germany

    E. Platzer & U. Meinl

  2. Medizinische Universitätsklinik und Poliklinik der Universität Erlangen-Nürnberg, Germany

    R. v. Roemeling

  3. Pathologisch-anatomisches Institut der Universität Erlangen-Nürnberg, Germany

    B. Kaduk

Authors
  1. E. Platzer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. v. Roemeling
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. Kaduk
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. U. Meinl
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Platzer, E., v. Roemeling, R., Kaduk, B. et al. Nierenbefall bei angioimmunoblastischer Lymphadenopathie mit hochgradiger Insuffizienz — Remission nach hochdosierter Corticoidgabe. Klin Wochenschr 59, 509–516 (1981). https://doi.org/10.1007/BF01696213

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01696213

Key words

Schlüsselwörter

Search

Navigation