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Erythropoietin levels in patients depositing autologous blood in short intervals

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Summary

Plasma immunoreactive erythropoietin (EPO) concentrations were studied in ten patients (7 men, 3 women) predonating autologous blood for hip arthroplasty. Donations were scheduled on day 1, 3, 7, 14 (and 21 if four units could not be donated previously). A predonation hemoglobin concentration of 11 g/dl was required. The donations led to a decline of the hemoglobin concentration from 14.1±1.0 g/dl (X±SD) prior to donation to 11.0±0.9 g/dl on day 15. EPO concentration prior to donation was 17.6±2.6 mU/ml. Each phlebotomy was followed by a rise in EPO levels that reached a peak concentration within 1 day. The highest concentration (35.8±15.0 mU/ml) was measured on day 16. The peak concentration was followed by a plateau at lower, although still elevated levels after the first and second donation, and by a slow, continuous decline after the third and fourth donation. This particular time course is similar to that during weekly donations [15]. The time integral of the EPO concentration during the first 3 weeks, however, was greater in the present study. This increased availability of EPO early during donation may lead to a more efficient stimulation of erythropoiesis.

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Authors and Affiliations

  1. Institut für Anästhesiologie und operative Intensivmedizin am Klinikum Mannheim der medizinischen Fakultät der Universität Heidelberg, Theodor-Kutzer-Ufer, W-6800, Mannheim, Germany

    A. Lorentz, P. M. Osswald & J. R. Duchow

  2. Physiologisches Institut der Universität Zürich, Zürich, Switzerland

    K. -U. Eckardt

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  1. A. Lorentz
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  2. K. -U. Eckardt
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  3. P. M. Osswald
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  4. J. R. Duchow
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Lorentz, A., Eckardt, K.U., Osswald, P.M. et al. Erythropoietin levels in patients depositing autologous blood in short intervals. Ann Hematol 64, 281–285 (1992). https://doi.org/10.1007/BF01695472

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  • DOI: https://doi.org/10.1007/BF01695472

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