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Neural cell adhesion molecule (NCAM) as a quantitative marker in synaptic remodeling

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Abstract

The neural cell adhesion molecule (NCAM) participates in adhesion and neuritic outgrowth during nervous system development. In the adult brain, NCAM is considered to be involved in neuronal sprouting and synaptic remodeling. the NCAM concentration of brain tissue has proved to be a useful marker of these processes, especially when viewed in comparison with the concentration of a marker of mature synapses, e.g. D3-protein (SNAP-25) or synaptophysin. The present review focusses on studies of adult brain in which NCAM concentration estimates and NCAM/D3 ratios have been used to evaluate the rate of synaptic remodeling in brain damage and degenerative diseases.

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  1. Laboratory of Neuropsychiatry, Department of Pharmacology, University of Copenhagen and University State Hospital, Rigshospitalet-6102, DK-2100, Copenhagen, Denmark

    Ole Steen Jørgensen

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Special issue dedicated to Dr. Robert Balázs.

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Jørgensen, O.S. Neural cell adhesion molecule (NCAM) as a quantitative marker in synaptic remodeling. Neurochem Res 20, 533–547 (1995). https://doi.org/10.1007/BF01694535

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