Abstract
The antipyretic activity of diclofenac sodium, 100 mg suppository was studied retrospectively in 21 applications in seven intensive care patients. Diclofenac sodium proved to be a very potent antipyretic agent with serious side effects. Acute oliguria and protracted circulatory shock occured after administration, necessitating the administration of increasing amounts of dopamine and i.v. fluids. Possible mechanisms involved are discussed.
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Donker AJM, Arisz L, Brentjens RJH, Hem GK van der, Hollemans HJG (1976) The effect of indomethacin on kidneyfunction and plasma renin activity in man. Nephron 17:228
Fejes-Toth G, Magyar A, Walter J (1977) Renal respons to vasopressin after inhibition of prostaglandin synthesis. Am J Physiol 232:416
Friedman PL, Brown EJ, Gunther S, Alexander RW, Barry WH, Mudge GH, Grossman W (1981) Coronary vasoconstrictor effect of indomethacin in patients with coronary artery disease. New Engl J Med 305:1171
Goodman and Gilman's (1980) The pharmacological basis of therapeutics 6th edn. Macmillan Publishing Co. Inc., New York
Halim AS, Sjöqvist B, Ångáard E (1976) Inhibition of prostaglandin biosynthesis in rat brain. Acta Physiol Scand (Suppl) 440:109
Horton R, Zipser R, Fickman M (1981) Prostaglandins renal function and vascular regulation. Med Cl North Am 65(4):91
Karim SMM, Somers K, Hillier K (1971) Cardiovascular and other effects of prostaglandin E2 and F2 in man. Cardiovasc Res 5:255
Keinanen-Kiukaaniemi A, Simila S, Kapyla H (1980) Antipyretic therapy: Evaluation of diclofenac sodium as an antipyretic agent. Clin Ther 2(6):421
Menassé R, Hedwall PR, Kreatz J, Pericin C, Riesterer L, Sallmann A, Ziel R, Jaques R (1978) Farmacological properties of diclofenac sodium and its metabolites. Scand J Rheumatol (Suppl) 22:5
Okuno T, Kondo K, Suzuki H (1981) Effect of prostaglandins E2, I2 and F3 Arachidonic acid and indomethacin on pressor responses to norepinephrine in concious rats. Prostaglandins 19(6):55
Polman HA, Huijbers WAR (1980) Toepassing van Voltaren® suppositoria (diclofenac) als antipyreticum bij kinderen met koorts ten gevolge van acute infecties. Rheuma Wereldwijd 4:11
Walshe JJ, Venuto RC (1979) Acute oliguric renal failure induced by indomethacin: possible mechanism. Ann Intern Med 91:47
Ziel R, Krupp PJ Effect on prostaglandin synthesis and antipyretic activity of non-steroidal anti-inflammatory agents. In: Lomav P, Shonbaum E, Jacob J. Karger Basel (eds) Temperature regulation and drug action. Ed., p. 223
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Zandstra, D.F., Stoutenbeek, C.P. & Alexander, J.P. Antipyretic therapy with diclofenac sodium. Intensive Care Med 9, 21–23 (1983). https://doi.org/10.1007/BF01693701
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DOI: https://doi.org/10.1007/BF01693701