Abstract
This study was undertaken to investigate the effects of prophylactic administration of cefaclor on bacteremia after dental extraction. Thirty-nine patients were randomly assigned to receive either 1 g cefaclor (19 patients) or placebo (20 patients) 1 h prior to dental extraction. Blood samples for microbiological investigation were collected before, during, and 10 min after surgery, and were processed by lysis filtration under anaerobic conditions. The incidence of bacteremia with viridans streptococci was 79% in the cefaclor group and 50% in the placebo group during extraction. No difference in the incidence or magnitude of bacteremia was observed when the two patient groups were compared.
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Young SEJ: Aetiology and epidemiology of infective endocarditis in England and Wales. Journal of Antimicrobial Chemotherapy 1987, 20, Supplement A: 7–14.
Heimdahl A, Hall G, Hedberg M, Sandberg H, Söder Pö, Tunér K, Nord CE: Detection and quantitation by lysisfiltration of bacteremia after different oral surgical procedures. Journal of Clinical Microbiology 1990, 28: 2205–2209.
Leport C, Horstkotte D, Burckhardt D: Antibiotic prophylaxis for infective endocarditis from an international group of experts towards a European consensus. European Heart Journal 1995, 16, Supplement B: 126–131.
Bill NJ, Washington JA: Comparison of in vitro activity of cephalexin, cephradine, and cefaclor. Antimicrobial Agents and Chemotherapy 1977, 11: 470–474.
Bisno AL, Dismukes WE, Durack DT, Kaplan EL, Karchmer AW, Kaye D, Rahimtoola SH, Sande MA, Sanford JP Watanakunakorn C, Wilson WR: Antimicrobial treatment of infective endocarditis due to viridans streptococci, enterococci, and staphylococci. Journal of the American Medical Association 1989, 261: 1471–1477.
Hall G, Hedström Så, Heimdahl A, Nord CE: Prophylactic administration of penicillins for endocarditis does not reduce the incidence of postextraction bacteremia. Clinical Infectious Diseases 1993, 17: 188–194.
Murray PR, Baron EJ, Pfaller MA, Tenover FC, Yolken RH: Manual of clinical microbiology. American Society for Microbiology, Washington, DC, 1995.
National Committee for Clinical Laboratory Standards: Performance standards for antimicrobial susceptibility testing; fourth informational supplement. M100-S4. NCCLS, Villanova, PA, 1992.
Hall G, Nord CE, Heimdahl A: Elimination of bacteraemia after dental extraction: comparison of erythromycin and clindamycin for prophylaxis of infective endocarditis. Journal of Antimicrobial Chemotherapy 1996, 37: 783–795.
Neu HC, Fu KP: Cefaclor: in vitro spectrum of activity and beta-lactamase stability. Antimicrobial Agents and Chemotherapy 1978, 13: 584–588.
Meyers BR, Hirschman SZ: Antimicrobial activity in vitro of cefaclor, a new oral cephalosporin. Journal of Clinical Pharmacology 1963, 18: 85–90.
Hodges GR, Liu C, Hinthorn DR, Harms JL, Dworzack DL: Pharmacological evaluation of cefaclor in volunteers. Antimicrobial Agents and Chemotherapy 1978, 14: 454–456.
Brennan RO, Durack DT: Therapeutic significance of penicillin tolerance in experimental streptococcal endocarditis. Antimicrobial Agents and Chemotherapy. 1983, 23: 273–277.
Hess J, Dankert J, Durack, D: Significance of penicillin tolerance in vivo: prevention of experimentalStreptococcus sanguis endocarditis. Journal of Antimicrobial Chemotherapy 1983, 11: 555–564.
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Hall, G., Heimdahl, A. & Nord, C.E. Effects of prophylactic administration of cefaclor on transient bacteremia after dental extraction. Eur. J. Clin. Microbiol. Infect. Dis. 15, 646–649 (1996). https://doi.org/10.1007/BF01691150
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DOI: https://doi.org/10.1007/BF01691150