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In vitro activity of nonsteroidal antiinflammatory agents, phenotiazines, and antidepressants againstBrucella species

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Abstract

The in vitro antimicrobial activity of streptomycin, rifampicin, tetracycline, seven nonsteroidal antiinflammatory agents (acetyl-salicylic acid, piroxicam, indomethacin, ibuprofen, ketoprofen, sulindac, and diclofenac), and eight phenotiazine derivatives and antidepressant agents (clorpromazine, fluphenazine, amitryptiline, clomipramine, imipramine, maprotiline, sertraline, and diazepam) against 62 strains ofBrucella spp. was tested. Diclofenac was the most active of the anti-inflammatory agents (MIC90 = 16 μg/ml). The activity of the phenotiazines and antidepressants was heterogeneous, with MIC90S ranging from 16 μg/ml for sertraline and 32 μg/ml for fluphenazine and clomipramine to > 512 μg/ml for diazepam. When the six most active anti-inflammatory agents and the six most active psychiatric drugs were tested at pH 5 and pH 4, the MICs remained unchanged except for those of fluphenazine; the MIC50 and MIC90 of this agent increased by one dilution.

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References

  1. García-Rodríguez JA, Garcia Sanchez JE, Muñoz Bellido JL, Ortiz de la Tabla V, Bellido Barbero J: Review of pulmonary brucellosis: a case report on brucellar pulmonary empyema. Diagnostic Microbiology & Infectious Disease 1989, 11: 53–60.

    Google Scholar 

  2. Gotuzzo E, Alarcón GS, Bocanegra TS: Articular involvement in human brucellosis. A retrospective analysis of 304 cases. Seminars in Arthritis and Rheumatism 1982, 12: 245–255.

    PubMed  Google Scholar 

  3. Rotés-Querol J: Osteo-articular sites of brucellosis. Annals of Rheumatic Diseases 1957, 16: 63–68.

    Google Scholar 

  4. Ariza J, Gudiol F, Valverde J: Brucellar spondylitis: a detailed analysis based on current findings. Reviews of Infectious Diseases 1985, 7: 656–664.

    PubMed  Google Scholar 

  5. Khateeb MI, Araj GF, Majeed SA:Brucella arthritis: a study of 96 cases in Kuwait. Annals of Rheumatic Diseases 1990, 49: 994–998.

    Google Scholar 

  6. Kristiansen JE: The antimicrobial activity of psychotherapeutic drugs and their stereo-isomeric analogues. Danish Medical Bulletin 1990, 37: 165–182.

    PubMed  Google Scholar 

  7. Basco LK, Le Bras J: Desipramine or cyproheptadine for reversing chloroquine resistance? Lancet 1990, i: 422.

    Google Scholar 

  8. García-Rodríguez JA, Muñoz-Bellido JL, Fresnadillo MJ, Trujillano I: In vitro activities of new macrolides and rifapentine againstBrucella spp. Antimicrobial Agents and Chemotherapy 1993, 37: 911–913.

    PubMed  Google Scholar 

  9. Thornberry C, Swenson JM, Baker CN, McDougal LK, Stocker SA, Hill BC: Susceptibility testing of fastidious and unusual pathogens. Antimicrobics Newsletter 1987, 4:47–55.

    Google Scholar 

  10. Helleberg L: Clinical pharmacokinetics of indomethacin. Clinical Pharmacology 1981, 6: 245–258.

    Google Scholar 

  11. Todd PA, Sorkin EM: Diclofenac sodium. A reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs 1988, 35: 244–258.

    PubMed  Google Scholar 

  12. Skeith KJ, Jamali F: Clinical pharmacokinetics of drugs used in juvenile arthritis. Clinical Pharmacokinetics 1991, 21: 129–149.

    PubMed  Google Scholar 

  13. Makelä AL, Lempiainen M, Ylijoki H: Ibuprofen levels in serum and synovial fluids. Scandinavian Journal of Rheumatology 1981, 7: 161–165.

    Google Scholar 

  14. Smith JW: Infectious arthritis. In: Mandell GL, Douglas GR, Bennett JE (ed): Principles and practice of infectious diseases. Churchill Livingstone, New York, 1990, p. 911–918.

    Google Scholar 

  15. Kristiansen JE: The antimicrobial activity of non-antibiotics. Acta Pathologica, Microbiologica, and Immunologica Scandinavica 1992, 100: 7–14.

    Google Scholar 

  16. Bitonti A, Sjoerdsma A, McCann A: Reversal of chloroquine resistance in malaria parasitePlasmodium falciparum. Science 1988, 242: 1301–1303.

    PubMed  Google Scholar 

  17. Bourdon JL: Contribution à l'étude des propriétés antibiotiques de la chlorpromazine. Annals of the Institut Pasteur (Paris) 1961, 101: 876–886.

    Google Scholar 

  18. Cowman AF, Karcz S, Galatis D, Culvenor JG: A P-glycoprotein homologue ofPlasmodium falciparum is located on the digestive vacuola. Journal of Cellular Biology 1991, 113: 1033–1042.

    Google Scholar 

  19. Coutaux AF, Mooney JJ, Wirth DF: Neuronal monoamine reuptake inhibitors enhance in vitro susceptibility to chloroquine inPlasmodium falciparum. Antimicrobial Agents and Chemotherapy 1994, 38: 1419–1421.

    PubMed  Google Scholar 

  20. Balaut-Gorgia AE, Gex-Fabry M, Balaut LP: Clinical pharmacokinetics of clomipramine. Clinical Pharmacokinetics 1991, 20: 447–462.

    PubMed  Google Scholar 

  21. Verghese C, Kessel JB, Simpson GM: Pharmacokinetics of neuroleptics. Psychopharmacology Bulletin 1991, 27: 551–563.

    PubMed  Google Scholar 

  22. DeVane CL: Pharmacokinetics of the selective serotonin reuptake inhibitors. Journal of Clinical Psychiatry 1992, 53, Supplement P: 13–20.

    Google Scholar 

  23. García-Rodríguez JA, García Sánchez JE, Trujillano I: Lack of effective bactericidal activity of new quinolones againstBrucella spp. Antimicrobial Agents and Chemotherapy 1991, 35: 756–759.

    PubMed  Google Scholar 

  24. Lang A, Raz R, Sachs T, Shapiro M: Failure of prolonged treatment with ciprofloxacin in acute brucellosis. Journal of Antimicrobial Chemotherapy 1990, 26: 841–846.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Microbiology, Hospital Clínico Universitario, Paseo de San Vicente 108, 37007, Salamanca, Spain

    S. Muñoz-Criado, X. L. Muñoz-Bellido & J. A. García-Rodríguez

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  1. S. Muñoz-Criado
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  2. X. L. Muñoz-Bellido
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  3. J. A. García-Rodríguez
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Muñoz-Criado, S., Muñoz-Bellido, X.L. & García-Rodríguez, J.A. In vitro activity of nonsteroidal antiinflammatory agents, phenotiazines, and antidepressants againstBrucella species. Eur. J. Clin. Microbiol. Infect. Dis. 15, 418–420 (1996). https://doi.org/10.1007/BF01690103

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