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Effect of methylmercury on humoral immune responses in mice under conditions simulated to practical situations

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Summary

A suppression and delay in reaching the peak of primary humoral response in mice was noted when relatively large dosage of methylmercury was administered in a short time period, suggesting the interference with the initial multiplications of antibody producing cells. On the other hand, sub chronic administration of low levels of methylmercury in diet (0.5 and 5 ppm) caused no definite suppression on either primary or secondary responses, though they tended to be depressed.

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Authors and Affiliations

  1. Department of Environmental Medicine, Tokyo Metropolitan Research Laboratory of Public Health, Shinjuku ku, 160, Tokyo, Japan

    G. Ohi, M. Fukuda, H. Seto & H. Yagyu

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  1. G. Ohi
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  2. M. Fukuda
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  3. H. Seto
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  4. H. Yagyu
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Ohi, G., Fukuda, M., Seto, H. et al. Effect of methylmercury on humoral immune responses in mice under conditions simulated to practical situations. Bull. Environ. Contam. Toxicol. 15, 175–180 (1976). https://doi.org/10.1007/BF01685157

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  • DOI: https://doi.org/10.1007/BF01685157

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