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Immunological and detoxication interaction in p,p-DDT fed rabbits

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Summary

Thirty-one rabbits were immunized against Salmonella or SRBC. These rabbits had an impaired immunological response when they received 200 ppm p,p′-DDT in their drinking water during a period of 38 days. The total gamma globulins as reflected by the 7 S fraction were significantly decreased in the p,p′-DDT-Salmonella receiving rabbits when compared with the rabbits receiving only Salmonella. This decrease was not statistically significant in the p,p′-DDT-SRBC receiving rabbits when compared with the rabbits receiving only SRBC.

The antibody titer against Salmonella was significantly decreased in p,p′-DDT-Salmonella receiving rabbits when compared with the rabbits receiving only Salmonella. The decrease of the SRBC antibody titer in the p,p′-DDT-SRBC receiving rabbits was not statistically significant.

The plasma total DDT level differed significantly in the two groups receiving p,p′-DDT (p,p′-DDT-Salmonella and p,p′-DDT-SRBC receiving rabbits). This finding may explain the different degree of impairment of the immunological response, the higher plasma DDT level having a more marked effect. These differences in total DDT plasma level in the two groups of rabbits which received the same amount of p,p′-DDT in their drinking water may be considered as a consequence of the concomitant presence of a different kind of foreign antigen in the internal milieu.

The bi-directional relationship between a detoxication process and an immunological response is emphasized.

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References

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Authors and Affiliations

  1. Department of Occupational Health, Hebrew University-Hadassah Medical School, Jerusalem, Israel

    M. Wassermann, Dora Wassermann, E. Kedar & M. Djavaherian

Authors
  1. M. Wassermann
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  2. Dora Wassermann
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  3. E. Kedar
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  4. M. Djavaherian
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Additional information

This investigation was supported by a grant from the World Health Organization, International Agency for Research on Cancer, Lyon.

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Wassermann, M., Wassermann, D., Kedar, E. et al. Immunological and detoxication interaction in p,p-DDT fed rabbits. Bull. Environ. Contam. Toxicol. 6, 426–435 (1971). https://doi.org/10.1007/BF01684364

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  • DOI: https://doi.org/10.1007/BF01684364

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