Summary
Dystonia occurs frequently following administration of neuroleptic or antiemetic drugs. This acute manifestation is not likely to be a simple consequence of reduced dopaminergic activity, because it was never reported to occur following the use of drugs which deplete dopamine stores, like reserpine and tetrabenazine. Based on the fact that dopamine-beta-hydroxylase levels are frequently elevated in patients with the dominant form of torsion dystonia it is suggested that dystonia results from impairment of a normal dopaminergic-noradrenergic balance, in which noradrenergic tone preponderates. A relative norepinephrine hyperactivity may be caused by dopaminergic blockade (as occurs in drug-induced dystonia) or from enhanced release of norepinephrine (in idiopathic torsion dystonia).
References
Calne, D. B.: Parkinsonism: Physiology, pharmacology and treatment. London: 1970.
Denny-Brown, D.: The Basal Ganglia and their relation to disorders of movement. London: 1962.
Fahn, S., Eldridge, R.: Advances in Neurology, Vol. 14 (Eldridge, R., Fahn, S., eds.), p. 1. New York: 1976.
Zeman, W.: Advances in Neurology, Vol. 14 (Eldridge, R., Fahn, S., eds.), p. 91. New York: 1976.
Duvoisin, R. C.: Psychopharmacology, a Review of Progress (Efron, D. H., ed.), p. 561. Washington, D.C.: 1967.
Korczyn, A. D., Goldberg, G. J. Brit. J. Psychiat.121, 75 (1972).
Eldridge, R. Neurology, Minneap. 1970, Supp. 20 (II, part 2), 1.
Editorial: Brit. Med. J.2, 1412 (1964).
Korczyn, A. D., Goldberg, G. J. J. Neurol. Neurosurg. Psychiat.39, 866 (1976).
Dolphin, A., Jenner, P., Marsden, C. D., Pycock, C., Tarsy, D. Psychopharmacologia (Berl.)41, 133 (1975).
Paulson, G. Dis. Nerv. Syst.21, 447 (1960).
Ayd, F. I. Psychosomatics1, 143 (1960).
Herz, E., Meyers, R.: Clinical Neurology (Baker, A. B., ed.) p. 726. London: 1955.
Curzon, G. Proc. R. Soc. Med.66, 873 (1973).
Wooten, G. F., Eldridge, R., Axelrod, J., Stern, R. New Engl. J. Med.288, 284 (1973).
Kanter, W., Wooten, G. F., Eldridge, R.: Advances in Neurology, Vol. 14 (Eldridge, R., Fahn, S., eds.), p. 303. New York: 1976.
Geffen, L. Life Sciences14, 1593 (1974).
Ebstein, R. P., Freedman, L. S., Lieberman, A., Park, D. H., Pasternack, B., Goldstein, M. Neurology (Minneap.)24, 684 (1974).
Ziegler, M. G., Lake, C. R., Eldridge, R., Kopin, I. J.: Plasma Norepinephrine and Dopamine-β-Hydroxylase in Dystonia. In: Advances in Neurology, Vol. 14 (Eldridge, R., Fahn, S., eds.), p. 307. New York: 1976.
Vogt, M. J. Physiol. (London)123, 451 (1954).
Lloyd, K. G. Pharmac. Ther.31, 49 (1975).
Bernheimer, H., Birkmayer, W., Hornykiewicz, O. Klin. Wschr.41, 465 (1963).
Marsden, C. D., Duvoisin, R. C., Jenner, P., Parkes, J. D., Pycock, C., Tarsy, D.: Advances in Neurology, Vol. 9 (Calne D. B., Chase, T. N., Barbeau, A., eds.), p. 165. New York: 1975.
Barbeau, A. Pharmac. Ther.1, 475 (1976).
Rinne, U. K., Sonninen, V. Arch. Neurol.28, 107 (1973).
Coleman, M. Neurology, Minneap.1970, Suppl. 20 (II, part 2), 114.
Barbeau, A. Neurology, Mineap.1970, Suppl. 20 (II, part 2), 96.
Yahr, M. D. Amer. Neurol. Assoc. Transac.94, 93 (1969).
Schmidt, R. T., Stahl, S. M., Spehlman, R. Neurology (Minneap.)25, 622 (1975).
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Korczyn, A.D. The pathophysiology of dystonia. J. Neural Transmission 42, 245–250 (1978). https://doi.org/10.1007/BF01675314
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DOI: https://doi.org/10.1007/BF01675314