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A new model for measuring concentration of antibiotics in prostatic interstitial fluid

Ein neues Modell zur Bestimmung von Antibiotikakonzentrationen in der interstitiellen Prostata-Flüssigkeit

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Summary

Utilizing multiperforated capsules implanted into subcutaneous tissue and the prostate in dogs, the concentration of cephalothin in soft tissue interstitial fluid (STIF) and prostatic interstitial fluid (PIF) was measured simultaneously and compared with concentration in serum. At all times the antibiotic concentration in PIF was lower than levels found in STIF and serum. This model may aid in the understanding of the basic pharmocokinetics of antibiotics in the prostatic interstitium and provide guidelines for treatment of prostatitis.

Zusammenfassung

Mittels implantierter perforierter Kapseln wurde die Konzentration von Cephalotin in der interstitiellen Flüssigkeit des Subkutangewebes (STIF) und der Prostata (PIF) gemessen und mit dem Serumspiegel verglichen. Die Antibiotikakonzentration im PIF war zu allen Zeiten niedriger als im STIF oder Serum. Dieses Modell trägt zum grundsätzlichen Verständnis der Pharmakokinetik im Prostatainterstitium bei und kann bei der Behandlung der Prostatitis Richtlinien geben.

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Literature

  1. Armstrong, J. R., Cook, F. E., Robinson, J. R. Concentration of antibiotic and chemotherapeutic agents in the ejaculum. J. Urol. 100 (1968) 72.

    Google Scholar 

  2. Blacklock, N. J. Anatomical factors in prostatitis. Brit. J. Urol. 46 (1974) 47.

    Google Scholar 

  3. Drach, G. W. Problems in diagnosis of bacterial prostatitis: gram-negative, gram-positive and mixed infections. J. Urol. 111 (1974) 630.

    Google Scholar 

  4. Eickenberg, H.-U., Scharfenberger, L., Waterman, N. G. Concentration of antibiotics in renal interstitial fluid: An experimental model. Urol. Res. 4 (1975) 1.

    Google Scholar 

  5. Kunin, C. M. Inhibitors of penicillin binding to serum proteins. J. Lab. Clin. Med. 65 (1965) 416.

    Google Scholar 

  6. Meares, E. M., Stamey, T. A. Bacteriologic localization patterns in bacterial prostatitis and urethritis. Invest. Urol. 5 (1968) 492.

    Google Scholar 

  7. Schmidt, J. D., Patterson, M. C. Needly biopsy study of chronic prostatitis. J. Urol. 96 (1966) 519.

    Google Scholar 

  8. Stamey, T. A., Meares, E. M., Jr., Winningham, D. G. Chronic bacterial prostatitis and the diffusion of drugs into prostatic fluid. J. Urol. 103 (1970) 187.

    Google Scholar 

  9. Waterman, N. G., Kastan, L. B. Interstitial fluid and serum antibiotic concentrations. Arch. Surg. 105 (1972) 192.

    Google Scholar 

  10. Waterman, N. G., Scharfenberger, L. Hepatic interstitial and wound fluid antibiotic concentrations. Surg. Gynecol. Obstet. 142 (1976) 235.

    Google Scholar 

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Authors and Affiliations

  1. Section of Urology, Department of Surgery, and the Price Institute of Surgical Research, University of Louisville School of Medicine, Health Sciences Center, 40201, Louisville, Kentucky, USA

    H. -U. Eickenberg, L. Scharfenberger &  N. G. Waterman

Authors
  1. H. -U. Eickenberg
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  2. L. Scharfenberger
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  3. N. G. Waterman
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Eickenberg, H.U., Scharfenberger, L. & Waterman, N.G. A new model for measuring concentration of antibiotics in prostatic interstitial fluid. Infection 4 (Suppl 2), S108–S112 (1976). https://doi.org/10.1007/BF01674479

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  • DOI: https://doi.org/10.1007/BF01674479

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