Skip to main content
Log in

Risk factors of ocular hypertension and glaucoma

The Casteldaccia Eye Study

  • Published:
Documenta Ophthalmologica Aims and scope Submit manuscript

Abstract

A case-control study was planned as a part of the Casteldaccia Eye Study in order to investigate about risk factors of ocular hypertension and glaucoma. Cases were 44 subjects with glaucoma or intraocular pressure of 24 mm Hg or more. Controls were 220 subjects with intraocular pressure of 20 mm Hg or less and no signs of glaucoma. A number of environmental, behavioral, systemic and ocular variables were studied. Among the others we investigated the following: sunlight exposure, smoking, alcohol intake, pregnancies, systemic hypertension, diabetes, use of corticosteroids, refractive status, anterior chamber depth, lens nuclear sclerosis, iris color and texture. After univariate analysis the use of ocular corticosteroids and antibiotics, myopia, shallow anterior chamber and myopic macular degeneration were associated with ocular hypertension or glaucoma. However, the logistic regression showed that only the use of ocular corticosteroids (odds ratio = 7.79) and the myopia (odds ratio = 5.56) were independently associated.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Davanger M, Ringvold A, Blidka S. The probability of having glaucoma at different IOP levels. Acta Ophthalmol 1991; 69: 565–8.

    Google Scholar 

  2. Seddon JM, Schwartz B, Flowerdew G. Case-control study of ocular hypertension. Arch Ophthalmol 1983; 101: 891–4.

    Google Scholar 

  3. Shiose Y. Intraocular pressure: New perspectives. Surv Ophthalmol 1990; 34: 413–35.

    Google Scholar 

  4. Klein BEK, Klein R, Linton KLP. Intraocular pressure in an American community. The Beaver Dam Eye Study. Invest Ophthalmol Vis Sci 1992; 33: 2224–8.

    Google Scholar 

  5. Ponte F, Giuffrè G, Ridola E. Faranda F, Di Pace F, Lacagnina T, Scimonelli E. Indagine epidemiologica oculare di Casteldaccia. Organizzazione dello studio e procedura d'esame. Boll Ocul 1992; 71: 931–6.

    Google Scholar 

  6. Ponte F, Giuffrè G, Giammanco R, Palumbo C, Oddo G, Messina M, Giuliano S. Indagine epidemiologica oculare di Casteldaccia. ‘Presentazione della scheda di rilevamento dati. Boll Ocul 1992; 71: 937–48.

    Google Scholar 

  7. Giuffrè G, Giammanco R, Di Pace F, Ponte F. Casteldaccia Eye Study. Prevalence of cataract on the adult and elderly population of a Mediterranean town. (in press).

  8. Van Herick W, Shaffer RN, Schwartz A. Estimation of width of angle of anterior chamber: Incidence and significance of the narrow angle. Am J Ophthalmol 1969; 68: 626–9.

    Google Scholar 

  9. Chylack LT, Leske MC, McCarthy D, Khu P, Kashiwagi T, Sperduto R. Lens opacities classification system II (LOCS II). Arch Ophthalmol 1989; 107: 991–7.

    Google Scholar 

  10. Woolf B. On estimating the relation between blood group and disease. Ann Hum Genet 1955; 19: 251–3.

    Google Scholar 

  11. Leske MC, Podgor MJ. Intraocular pressure, cardiovascular risk variables, and visual field defects. Am J Epidemiol 1983; 118: 280–7.

    Google Scholar 

  12. Shiose Y, Kawase Y. A new approach to stratified normal intraocular pressure in a general population. Am J Ophthalmol 1986; 101: 714–21.

    Google Scholar 

  13. Bulpitt CJ, Hodes C, Everitt MG. Intraocular pressure and systemic blood pressure in the elderly. Br J Ophthalmol 1975; 59: 717–20.

    Google Scholar 

  14. Klein BEK, Klein K. Intraocular pressure and cardiovascular risk variables. Arch Ophthalmol 1981; 99: 837–9.

    Google Scholar 

  15. Carel RS, Korczyn AD, Rock M, Goya I. Association between ocular pressure and certain health parameters. Ophthalmology 1984; 91: 311–4.

    Google Scholar 

  16. David R, Zangwill L, Stone D, Yassur Y. Epidemiology of intraocular pressure in a population screened for glaucoma. Br J Ophthalmol 1987; 71: 766–71.

    Google Scholar 

  17. Traisman HS, Alfano JE, Andrews J, Gatti R. Intraocular pressure in juvenile diabetics. Am J Ophthalmol 1967; 64: 1149–51.

    Google Scholar 

  18. Klein BEK, Klein R, Moss SE. Intraocular pressure in diabetic persons. Ophthalmology 1984; 91: 1356–60.

    Google Scholar 

  19. Hiller R, Sperduto RD, Kreuger DE. Race, iris pigmentation, and intraocular pressure. Am J Epidemiol 1982; 115: 674–83.

    Google Scholar 

  20. Wallace J, Lovell HG. Glaucoma and intraocular pressure in Jamaica. Am J Ophthalmol 1969; 67: 93–100.

    Google Scholar 

  21. Perkins ES, Phelps CD. Open-angle glaucoma, ocular hypertension, low-tension glaucoma, and refraction. Arch Ophthalmol 1982; 100: 1464–7.

    Google Scholar 

  22. David R, Zangwill L, Tessler Z, Yassur Y. The correlation between intraocular pressure and refractive status. Arch Ophthalmol 1985; 103: 1812–5.

    Google Scholar 

  23. Rubino A, Ponte F. La sindrome glaucomatosa nella miopia di grado elevato. Rilievi statistici e clinico-nosologici. Proc 43th Congr Società Oftalmologica Italiana. Roma: Arte della Stampa, 1963; 53–64.

    Google Scholar 

  24. Daubs JG, Crick RP. Effect of refractive error on the risk of ocular hypertension and open-angle glaucoma. Trans Ophthalmol Soc UK 1981; 101: 121–6.

    Google Scholar 

  25. Becker B, Hahn KA. Topical corticosteroids and heredity in primary open-angle glaucoma. Am J Ophthalmol 1964; 57: 543–51.

    Google Scholar 

  26. Miller D, Peczon JD, Whitworth CG. Corticosteroids and functions in the anterior segment of the eye. Am J Ophthalmol 1965; 59: 31–4.

    Google Scholar 

  27. Schwartz B. The response of ocular pressure to corticosteroids. Int Ophthalmol Clin 1966; 6: 929–45.

    Google Scholar 

  28. Armaly MF. Inheritance of dexamethasone hypertension and glaucoma. Arch Ophthalmol 1967; 77: 747–51.

    Google Scholar 

  29. Weinreb RN, Polansky JR, Kramer SG, Baxter JD. Acute effects of dexamethasone on intraocular pressure in glaucoma. Invest Ophthalmol Vis Sci 1985; 26: 170–5.

    Google Scholar 

  30. Knepper PA, Collins JA, Frederick R. Effect of dexamethasone, progesterone, and testosterone on IOP and GAGs in the rabbit eye. Invest Ophthalmol Vis Sci 1985; 26: 1093–1100.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ponte, F., GiuffrÉ, G., Giammanco, R. et al. Risk factors of ocular hypertension and glaucoma. Doc Ophthalmol 85, 203–210 (1994). https://doi.org/10.1007/BF01664928

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01664928

Key words

Navigation