Summary
Prostaglandin E1 is offered as a new therapeutic agent in the treatment of severe peripheral arterial occlusive disease. Especially when treating patients with ulcers or gangrene, the oxygen tension of the skin should improve during PGE1 administration. The new technique of assessing skin surface oxygen pressure histograms allows study of the skin microcirculation in vivo. Oxygen histograms were determined on the forefeet of 19 patients with different degrees of disease and different occlusion levels before and during a single intraarterial infusion of PGE1 at a dosage of 1.5 ng/kg body weight/min. Only 9 patients showed improvement during the infusion period. Skin oxygen pressure was increased to a large extent only in patients assumed to suffer from diabetic microangiopathy. The effect of a long-term therapy with PGE1 on skin microcirculation remains to be settled.
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Abbreviations
- PGE1 :
-
prostaglandin E1
- TcPO2 :
-
transcutaneous oxygen pressure
References
Böhme H, Brülisauer M, Härtel U, Bollinger A (1988) Kontrollierte Zweizentren-Studie zur Wirksamkeit von intraarteriellen Prostaglandin E1 Infusionen bei peripherer arterieller Verschlu\krankheit im Stadium III and IV. In: Heidrich H, Böhme H, Rogatti W (eds) Prostaglandin E1: Wirkungen und therapeutische Wirksamkeit. Springer, Berlin, p 118
Boulton AJM, Scarpello JHB, Ward JD (1982) Venous oxygenation in the diabetic neuropathic foot: evidence for arteriovenous shunting? Diabetologia 22:6
Corbin DOC, Young RJ, Morrison DC, Hoskins P, Dicken WN, Housley E, Clark BF (1987) Blood flow in the foot, polyneuropathy and foot ulceration in diabetes mellitus. Diabetologia 30:468
Creutzig A, Lux M, Alexander K (1984) Muscle tissue oxygen pressure fields and transcutaneous oxygen pressure in healthy men during intra-arterial prostaglandin E1 infusion. Int Angiol S3:105
Creutzig A, Creutzig H, Alexander K (1986) Effects of intraarterial prostaglandin E1 in patients with peripheral arterial occlusive disease. Eur J Clin Invest 16:480
Creutzig A, Caspary L, Ranke C, Kiessling D, Wilkens J, Frölich J, Alexander K (1987) Transcutaner PO2 and Laser Doppler Flux bei steigenden Dosierungen von intraarteriell und intravenös appliziertem Prostaglandin E1. Vasa 16:114
Creutzig A, Dau D, Caspary L, Alexander K (1987) Transcutaneous oxygen pressure measured at two different electrode core temperatures in healthy volunteers and patients with arterial occlusive disease. Int J Microcirc: Clin Exp 5:372
Creutzig A, Caspary L, Alexander K (1989) Skin surface oxygen pressure in healthy volunteers and patients with arterial occlusive disease. Int J Microcirc: Clin Exp (submitted)
Davies E (1979) The microcirculation in diabetes. Karger, Basel
Fontaine R (1953) Resultats des operations hyperemisantes dans les obliterations arterielles chroniques spontanées des membres. Rev Chir 72:204
Lindgren BW (1969) Statistical theory. Macmillan, New York, p 334
Parkhouse N, Le Quesne PM (1988) Impaired neurogenic vascular response in patients with diabetes and neuropathic foot lesions. N Engl J Med 318:1306
Stiegler H, Rett K, Wicklmayr M, Dietze K, Mehnert H (1988) Metabolic effects of prostaglandin E1 on human skeletal muscle. Vasa 17:5
Trübestein G, Ludwig M, Diehm C, Gruss JD, Horsch S (1987) Prostaglandin E1 bei arterieller Verschlu\krankheit im Stadium III und IV. Dtsch med Wochenschr 112:955
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Creutzig, A., Caspary, L. & Alexander, K. Skin surface oxygen pressure fields during administration of prostaglandin E1 in patients with arterial occlusive disease. Klin Wochenschr 68, 207–212 (1990). https://doi.org/10.1007/BF01662716
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DOI: https://doi.org/10.1007/BF01662716