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Clinical evaluation of ofloxacin in lower respiratory tract infections

Klinische Prüfung von Ofloxacin bei Infektionen der tiefen Atemwege

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Summary

The clinical efficacy and the safety of ofloxacin in lower respiratory tract infections were evaluated by 42 research groups in Japan. 127 patients with bacterial pneumonia and 399 patients with chronic lower respiratory tract infection were analyzed for clinical efficacy. The drug was orally administered, mostly in daily doses of 300 mg to 600 mg for an average of 15 days. The therapeutic success rate was 80% in bacterial pneumonias and 78% in chronic lower respiratory tract infections. As for bacteriological response, eradication rates of 93% and 72%, respectively, were observed against isolates from bacterial pneumonias and chronic lower respiratory tract infections. Side effects mainly in the gastrointestinal tract and central nervous system were noted in 7.6% of 540 patients, but none of them was severe.

Zusammenfassung

Die klinische Wirksamkeit und Sicherheit von Ofloxacin in der Behandlung von Infektionen der tiefen Atemwege wurde von 42 Forschergruppen in Japan geprüft. Bei 127 Patienten mit bakterieller Pneumonie und bei 399 Patienten mit chronischen Infektionen der tiefen Atemwege wurde die klinische Wirksamkeit von Ofloxacin untersucht. Das Medikament wurde oral verabreicht, die Dosierung lag in den meisten Fällen zwischen 300 und 600 mg Ofloxacin pro Tag; die Behandlungsdauer betrug im Durchschnitt 15 Tage. 80% der Patienten mit bakterieller Pneumonie und 78% der Patienten mit chronischen Atemwegsinfektionen sprachen auf die Therapie an. 93% der Erreger bakterieller Pneumonien und 72% der von chronischen Infektionen der tiefen Atemwege isolierten pathogenen Keime wurden eliminiert. Bei 7,6% der insgesamt 540 behandelten Patienten traten Nebenwirkungen auf, vorwiegend von seiten des Gastrointestinaltraktes und Zentralnervensystems. In keinem Fall traten schwere Nebenwirkungen auf.

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  1. Respiratory Research Section, First Department of Internal Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka City, 181, Tokyo, Japan

    H. Kobayashi M.D.

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Kobayashi, H. Clinical evaluation of ofloxacin in lower respiratory tract infections. Infection 14 (Suppl 4), S279–S282 (1986). https://doi.org/10.1007/BF01661294

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