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In vitro activity of ofloxacin against 210 clinical isolates of typhoid salmonellae

In vitro-Aktivität von Ofloxacin gegen 210 Isolate von Typhus-Salmonellen

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Summary

210 clinical isolates of typhoid salmonellae, cultivated from blood of patients with typhoid fever (108 strains ofSalmonella typhi, 99 strains ofSalmonella paratyphi A and three strains ofSalmonella paratyphi B) as well as 266 random clinical isolates ofEscherichia coli (n=152),Klebsiella spp. (n=51) andProteus spp. (n=63) were tested for susceptibility to ofloxacin, using an agar dilution method. All the typhoid salmonellae were found to be highly sensitive to ofloxacin with MICs ranging from 0.03 mg/l to 0.12 mg/l. The sensitivity pattern of enterobacteriaceae was comparable to data published internationally.

Zusammenfassung

210 klinische Isolate vonSalmonella typhi (n=108),Salmonella paratyphi A (n=99) undSalmonella paratyphi B (n=3), die aus Blutkulturen von Typhuspatienten gezüchtet worden waren, sowie 266 unausgewählte klinische Isolate vonEscherichia coli (n=152),Klebsiella spp. (n=51) undProteus spp. (n=63) wurden mittels Agardilutionstest auf ihre Empfindlichkeit gegenüber Ofloxacin geprüft. Alle Typhus-Salmonellen erwiesen sich als hochempfindlich gegen Ofloxacin (MHK-Werte 0,03 mg/l bis 0,12 mg/l); die getesteten Enterobacteriaceae entsprachen in ihrem Empfindlichkeitsverhalten international mitgeteilten Werten.

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Literature

  1. Knothe, H.: Gyrase inhibitors, a new group of antimicrobial agents. Quinolones Bull. 1984.

  2. Krech, T., Naumann, P., Dopp, Ch., et al: Antibacterialin vitro activity of norfloxacin, ciprofloxacin, ofloxacin and pefloxacin. Proceedings 4th Mediterranean Congress of Chemotherapy, Greece 1984, pp. 447–449.

  3. Loza, E., Gomez-Alfrez, A., Torres, C.: Ofloxacin:in vitro activity against clinical isolates. Proceedings 4th Mediterranean Congress of Chemotherapy, Greece 1984, pp. 426–429.

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Hannan, A. In vitro activity of ofloxacin against 210 clinical isolates of typhoid salmonellae. Infection 14 (Suppl 4), S243–S244 (1986). https://doi.org/10.1007/BF01661282

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  • DOI: https://doi.org/10.1007/BF01661282

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