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Hominoid evolution as judged by fibrinopeptide structures

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Summary

The fibrinopeptides A and B from gorilla, organgutan and siamang have been characterized, thereby completing a study of all six extant hominoids. The gorilla peptides were identical with the corresponding fibrinopeptides previously reported for human and chimpanzee. The orangutan peptide A was also identical with the human-chimpanzee-gorilla type A, but its fibrinopeptide B had two amino acid differences. The siamang A peptide differed from the others in one of its sixteen residues, but its peptide B was identical with the orangutan B. A cladogram based on the fibrinopeptide sequences of all six hominoids indicates that five amino acid replacements and one deletion can account for the evolution of present day sequences. It was also possible to deduce the amino acid sequence of the fibrinopeptides of the common ancestor of Old World monkeys and hominoids.

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Abbreviations

PITC:

phenylisothiocyanate

DNS:

dimethylaminonaphthalene sulfonyl-

PCA:

pyrrolidone carboxylic acid

ASP:

aspartic acid

ASN:

asparagine

THR:

threonine

SER:

serine

GLU:

glutamic acid

GLN:

glutamine

GLY:

glycine

ALA:

alanine

VAL:

valine, ILE isoleucine

LEU:

leucine

PHE:

phenylalanine

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Authors and Affiliations

  1. Department of Chemistry, Revelle College, University of California, P.O. Box 109, 92037, La Jolla, California, USA

    R. F. Doolittle, G. L. Wooding, Y. Lin & M. Riley

Authors
  1. R. F. Doolittle
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  2. G. L. Wooding
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  3. Y. Lin
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  4. M. Riley
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Additional information

Supported by grants from the National Science Foundation (GB 7332) and the National Institutes of Health (GM-17, 702 and HE-12, 759).

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Doolittle, R.F., Wooding, G.L., Lin, Y. et al. Hominoid evolution as judged by fibrinopeptide structures. J Mol Evol 1, 74–83 (1971). https://doi.org/10.1007/BF01659395

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  • DOI: https://doi.org/10.1007/BF01659395

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