Abstract
Therapeutic measurements for acute pancreatitis depend on the severity of the disease and its complications. Since complications of acute pancreatitis may develop at any time, patients should be admitted to an intensive care unit for assessment (and frequent reassessment) of the severity of the disease and of the development of complications; they should remain in the intensive care unit for the first 48 hours at least, even if no signs of shock are apparent. The only exceptions to this rule are mild cases without signs of peritonitis. Basic therapy should include relief of pain, total fasting, nasogastric suction, parenteral replacement of fluids, electrolyte, albumin, and blood, and antibiotics. Hyperglycemia should be corrected and heparin should be given in cases of disseminated intravascular coagulation. In renal insufficiency, peritoneal dialysis is important, and in respiratory complications, humidified oxygen or artificial ventilation including positive end expiratory pressure therapy should be applied. Although the effect of peritoneal dialysis has been proven only in animal experiments and in retrospective studies in man, it is recommended in severe cases for shock therapy and for correction of electrolyte imbalance when ascites is present, even before anuria occurs.
Résumé
Les principes de traitement de la pancréatite aigüe dépendent de la gravité de la maladie et de ses complications. Comme cellesci peuvent apparaître n'importe quand, le malade doit être placé dans une unité de soins intensifs pour surveillance constante et appréciation continue de la gravité de son état. Il doit rester dans cette unité pendant les 48 premières heures au moins, même s'il n'a aucun signe de choc. La seule exception à cette règle peut être la pancréatite bénigne sans signe de péritonite. Le traitement de base doit comporter des antalgiques, un jeûne absolu, l'aspiration gastrique, des antibiotiques, le remplacement par voie parentérale de l'eau, des électrolytes, de l'albumine et du sang. Toute hyperglycémie doit être corrigée. Il faut administrer de l'héparine s'il y a coagulation intravasculaire disséminée. La dialyse péritonéale est importante en cas d'insuffisance rénale. Toute complication pulmonaire exige de l'oxygène humidifié ou un respirateur avec PEEP. L'effet bénéfique de la dialyse péritonéale n'a été démontré que chez l'animal et dans des études rétrospectives chez l'homme; il faut cependant la recommander en cas de choc grave et pour corriger les désordres électrolytiques s'il y a de l'ascite, même avant que ne survienne l'anurie.
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Creutzfeldt, W., Lankisch, P.G. Intensive medical treatment of severe acute pancreatitis. World J. Surg. 5, 341–348 (1981). https://doi.org/10.1007/BF01657992
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DOI: https://doi.org/10.1007/BF01657992