Skip to main content
Log in

Aspiration biopsy cytology in diagnosis of thyroid cancer

  • Published:
World Journal of Surgery Aims and scope Submit manuscript

Abstract

Aspiration biopsy cytology (ABC) is a diagnostic method that has been used extensively in Sweden for a quarter of a century. The technical steps involved in this biopsy procedure are described, and the differences from large needle biopsy techniques are pointed out. An overview is given of the different pathologic conditions that present as thyroid nodules and are recognizable by ABC. The accuracy of the method as a preoperative diagnostic tool has been shown to be superior to other clinical methods. ABC enables the surgeon not only to better select patients with thyroid nodules for surgery, but also to plan a definite operative strategy in papillary, medullary, and anaplastic neoplasms. In follicular neoplasms, however, the method cannot distinguish with certainty between adenoma and carcinoma. ABC has drastically reduced the number of diagnostic surgical operations for benign lesions. It requires no anesthesia. It has no complications and there is good patient acceptance, even in children.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. National Board of Health and Welfare. The Cancer Registry. Cancer incidence in Sweden 1973, Stockholm, Gotab, 1979

    Google Scholar 

  2. Katz, A.D., Warren, J.Z.: The malignant “cold” nodule of the thyroid. Am. J. Surg.132:459, 1976

    Google Scholar 

  3. Psarras, A., Papadopoulos, S.N., Livadas, D., Pharmakiotis, A.D., Kontras, D.A.: The single thyroid nodule. Br. J. Surg.59:545, 1972

    Google Scholar 

  4. Söderström, N.: Aspiration biopsy puncture of goiters for aspiration biopsy. Acta Med. Scand.144:237, 1952

    Google Scholar 

  5. Einhorn, J., Franzén, S.: Fine-needle biopsy in the diagnosis of thyroid disease. Acta Radiol. (Stockh.)58:321, 1962

    Google Scholar 

  6. Persson, P.S.: Cytodiagnosis of thyroiditis. A comparative study of cytological, histological, immunological and clinical findings in thyroiditis, particularly in diffuse lymphoid thyroiditis. Acta Med. Scand. (suppl.)483:8, 1967

    Google Scholar 

  7. Löwhagen, T.: Thyroid. In Aspiration Biopsy Cytology. Part 1. Cytology of Supradiaphragmatic Organs, Wied, G., Zajicek, J., editors, Monographs in clinical cytology, vol. 4, Basel, Karger, 1974, pp. 67–89

    Google Scholar 

  8. Söderström, N., Telenius-Berg, M., Akerman, M.: Diagnosis of medullary carcinoma of the thyroid by fine needle aspiration biopsy. Acta Med. Scand.197:71, 1975

    Google Scholar 

  9. Lopes Cardozo, P.: Atlas of Clinical Cytology (Lopes Cardozo, private publication), 1976, pp. 566–585

  10. Frable, W.J.: Thin-needle aspiration biopsy. Am. J. Clin. Pathol.65:168, 1976

    Google Scholar 

  11. Galvan, G., Pohl, G.B., Skerbisch, I.: Die Feinnadelpunktion “kalter.” Strumaknoten bei 4555 Patienten eines Strumaendemiegebiets. Schweiz. Med. Wochenschr.106:1247, 1976

    Google Scholar 

  12. Gershengorn, M.C., McClung, M.R., Chu, E.W., Hansson, T.A.S., Weintraub, B.D., Robbins, J.: Fine-needle aspiration cytology on the preoperative diagnosis of thyroid nodules. Ann. Intern. Med.87:265, 1977

    Google Scholar 

  13. Droese, M.: Aspiration biopsy cytology in the diagnosis of thyroid tumors. Verh. Dtsch. Ges. Pathol.61:283, 1977

    Google Scholar 

  14. Lang, W., Atay, Z., Georgii, A.: The cytological classification of follicular tumors in the thyroid gland. Virchows Arch. [Pathol. Anat.]378:199, 1978

    Google Scholar 

  15. Esselstyne, C.B., Jr., Crile, G., Jr.: Needle aspiration and needle biopsy of the thyroid. World J. Surg.2:321, 1978

    Google Scholar 

  16. Miller, M.J., Hamburger, J.I., Kini, S.: Diagnosis of thyroid nodules. J.A.M.A.241:481, 1979

    Google Scholar 

  17. Hamburger, J.I., Miller, J.M., Kini, S.: Clinical-Pathological Evaluation of Thyroid Nodules. Handbook and Atlas, limited edition (Hamburger, private publication, 1979)

    Google Scholar 

  18. Löwhagen, T., Granberg, P.-O., Lundell, G., Skinnari, P., Sundblad, R., Willems, J.-S.: Aspiration biopsy cytology (ABC) in tumors of the thyroid gland suspected to be malignant. Surg. Clin. North Am.59:3, 1979

    Google Scholar 

  19. Wang, C.A., Vickery, A.L., Jr., Maloof, F.: Needle biopsy of the thyroid. Surg. Gynecol. Obstet.143:365, 1976

    Google Scholar 

  20. Engzell, U., Esposti, P.L., Rubio, C.: Investigation on tumor spread in connection with aspiration biopsy. Acta Radiol. [Ther.] (Stockh.)10:385, 1971

    Google Scholar 

  21. Boon, M.E., Löwhagen, T., Willems, J.-S.: Planimetric studies on fine-needle aspirates from follicular adenoma and follicular carcinoma of the thyroid. Acta Cytol. (Baltimore)24: 145, 1980

    Google Scholar 

  22. Willems, J.-S., Löwhagen, T., Palombini, L.: The cytology of a giant-cell, osteoclastoma-like malignant thyroid neoplasm. A case report. Acta Cytol. (Baltimore)23:3, 214, 1979

    Google Scholar 

  23. Löwhagen, T., Willems, J.-S.: Aspiration Biopsy Cytology in Diseases of the Thyroid. Advances in Clinical Cytology. Koss, L., Coleman, D. Editors. London, Butterworths, (in press)

  24. Bondesson, L., Ljungberg, O.: Occult thyroid carcinoma at autopsy in Malmö, Sweden. Cancer (in press)

  25. Fukunaga, F.H., Yatami, R.: Geographic pathology of occult thyroid carcinomas. Cancer36:1095, 1975

    Google Scholar 

  26. Franssila, K., Saxén, E.: Histologic classification as a problem in the epidemiology of thyroid cancer. Recent results. Cancer Res.39:47, 1972

    Google Scholar 

  27. Saxén, E., Franssila, K., Bjarnason, O., Normann, T., Ringertz, N.: Observer variation in histologic classification of thyroid cancer. Acta Pathol. Microbiol. Scand. [A]86:483, 1978

    Google Scholar 

  28. Hedinger, C., Sobin, L.H.: International histological classification of tumors nr 11. Histological typing of thyroid tumors, Geneva, World Health Organization, 1974

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Löwhagen, T., Willems, JS., Lundell, G. et al. Aspiration biopsy cytology in diagnosis of thyroid cancer. World J. Surg. 5, 61–70 (1981). https://doi.org/10.1007/BF01657837

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01657837

Keywords

Navigation