Abstract
The results of treatment with intraoperative and external beam radiation for patients with carcinoma of the pancreas are presented. Among patients treated with125I implants for localized unresectable disease, local control rates ranged from 67% to 93% and median survival ranged from 7 to 12 months. In a series using intraoperative electron beam boosts, a 59% local control rate with a median survival of 16 months was achieved. Good palliation rates were achieved, although a high proportion of fatal complications occurred in one125I series. Less promising results were seen in patients receiving intraoperative radiation following resections, with a local control rate of 50% and a median survival of 7 months in a series of 10 patients.
Resumen
Se presentan los resultados del tratamiento con irradiación intraoperatoria y con irradiación externa para carcinoma de páncreas.
Entre los pacientes tratados con implantes de yodo-125 para enfermedad localizada no resecable, las tasas de control local oscilaron entre 67% y 93% y la supervivencia media varió entre 7 y 12 meses. En una serie en la cual se utilizó una sobredosis intraoperatoria con haz de electrones, se logró una tasa de control local de 59% con una supervivencia media de 16 meses. En una de las series con I-125 se obtuvieron buenas tasas de paliación, aún cuando hubo una elevada proporción de complicaciones fatales. Resultados menos promisorios fueron observados en una serie de 10 pacientes que recibieron irradiación intraoperatoria después de la resección, con una tasa de control local de 50% y una supervivencia media de 7 meses.
Similar content being viewed by others
References
Tepper, J.E., Nardi, G.L., Suit, H.D.: Carcinoma of the pancreas: Review of MGH experience from 1963–1973. Cancer Stud.7:1519, 1975
Al-Abdulla, A.M., Hussey, D.H., Olson, M.H., Wright, A.E.: Experience with fast neutron therapy for unresectable carcinoma of the pancreas. Int. J. Radiat. Oncol. Biol. Phys.7:165, 1981
Kaul, R., Cohen, L., Hendrikson, F.: Pancreatic carcinoma: Results with fast neutron therapy. Int. J. Radiat. Oncol. Biol. Phys.7:173, 1981
Castro, J.R., Quivey, J.M., Lyman, J.T., et al.: Current status of clinical particle radiotherapy at Lawrence-Berkeley Laboratory. Cancer46:633, 1981
Hilaris, B.S., Rousis, K.: Cancer of the pancreas. In Handbook of interstitial radiotherapy, B.S. Hilaris, ed. Acton, Mass., Publishing Science Group Incorporated, 1975, pp. 251–262
Goldson, A.L., Ashaveri, E., Spinoza, M.K., et al.: Single high dose intraoperative electrons for advanced stage pancreatic cancer: Phase I pilot study. Int. J. Radiat. Oncol. Biol. Phys.7:869, 1981
Shipley, W.U., Nardi, G.L., Cohen, A.M., Ling, C.G.: Iodine-125 implant and external beam irradiation in patients with localized pancreatic carcinoma. Cancer45:709, 1980
Whittington, R., Dobelbower, R.R., Mohiuddin, M., et al.: Radiotherapy of unresectable pancreatic carcinoma: A six-year experience with 104 patients. Int. J. Radiat. Oncol. Biol. Phys.7:1639, 1981
Mohiuddin, M., Whittington, R., Dobelbower, R.R., et al.: Iodine-125 implantation in the treatment of patients with unresectable pancreas carcinoma. Int. J. Radiat. Oncol. Biol. Phys.9:99, 1983
Abe, M., Takahashi, M., Yabumoto, E., et al.: Clinical experiences with intraoperative radiotherapy of locally advanced cancer. Cancer45:40, 1980
Gunderson, L.L., Tepper, J.E., Biggs, P.J., et al.: Intraoperative and external beam irradiation. Curr. Probl. Cancer, vol. 7, no. 11, May 1983
Tryka, A.F., Brooks, J.R.: Histopathology in evaluation of total pancreatectomy for ductal carcinoma. Ann. Surg.190:373, 1979
Edis, A.J., Kiernan, P.D., Taylor, W.S.: Attempted curative resection of ductal carcinoma of the pancreas. Mayo Clin. Proc.55:531, 1980
Anderson, J.F., Friis-Moller, A., Hancke, S., et al.: A controlled trial of combination chemotherapy with 5-FU and BCNU in pancreatic cancer. Scand. J. Gastroenterol.16:973, 1981
Author information
Authors and Affiliations
Additional information
Some of the material in this report was presented at the Annual Meeting of the American Surgical Association, Toronto, Canada, April 25–27, 1984, and published in the Annals of Surgery (in press). Supported in part by National Cancer Institute Contract No 1-CM-17481.
Rights and permissions
About this article
Cite this article
Shipley, W.U., Tepper, J.E., Warshaw, A.L. et al. Intraoperative radiation therapy for patients with pancreatic carcinoma. World J. Surg. 8, 929–934 (1984). https://doi.org/10.1007/BF01656034
Issue Date:
DOI: https://doi.org/10.1007/BF01656034