Abstract
Induction of hyperthermia in dogs by irrigation of the peritoneal cavity via a closed circuit system was evaluated for possible use in the management of cancer patients. Dogs were subjected to lavage of the peritoneal cavity with crystalloid solution at 41°–43°C in a closed circuit system. Temperatures of the liver and hollow viscera were maintained at 40°–42°C for 4 hours. The animals tolerated the procedure, and the parietal incisions and intestinal anastomoses healed without difficulty. Evidence of toxicity was minimal. Plans for studies of this modality in patients with cancer are underway.
Résumé
La tolérance à l'irrigation de la cavité péritonéale par une solution chaude contenant des électrolytes a été étudiée chez le chien dans le but de provoquer une hyperthermie régionale et d'appliquer cette méthode à l'homme atteint d'un processus tumoral abdominal. L'irrigation a été réalisée avec une solution dont la température allait de 41 à 43°C et à l'aide de cathéters intra-péritonéaux réalisant un circuit fermé.
Les résultats de l'expérimentation se sont soldés par un taux élevé de survie et un taux faible de complications. Ces faits ont démontré que la méthode pouvait s'appliquer à l'homme. L'hyperthermie régionale obtenue par l'irrigation intra-péritonéale avec un liquide chaud renforce chez le cancéreux l'action des radiations ionisantes et des drogues anti-mitotiques.
Resumen
La tolerancia de los animales a la irrigación de la cavidad peritoneal con solución electrolítica caliente fue estudiada en perros en preparación para la aplicación de esta modalidad en el manejo de pacientes con cancer. Mediante laparotomía se colocaron catéteres en la cavidad peritoneal, los cuales fueron utilizados para irrigar con solución electrolítica calentada a un nivel de 41° a 43°C. La operación, la exposición y el lavado peritoneal fueron bien tolerados por los animales, habiéndose observado una alta tasa de supervivencia y una baja tasa de complicaciones, lo cual indica que este procedimiento podría ser adaptado para uso en humanos. Existe un gran volumen de evidencia que señala que la irrigación de la cavidad peritoneal, de tipo agudo o crónico, es un procedimiento seguro. Las temperaturas supranormales, las cuales actúan potenciando la acción de las radiaciones ionizantes o de las drogas anticancerosas en el manejo de pacientes con cáncer, pueden ser producidas, mediante la técnica que aquí se informa, con secuelas tolerables.
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Supported in part by Grant #68930 from NIH Biomedical Research Funds.
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Smith, G.V., MacMillan, R. & Stribling, J. Intraperitoneal approach to regional hyperthermia—possible anticancer applications. World J. Surg. 7, 732–737 (1983). https://doi.org/10.1007/BF01655213
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DOI: https://doi.org/10.1007/BF01655213