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Plasma-Endothelin bei Normalpersonen und Patienten mit nephrologisch-rheumatologischen und kardiovaskulären Erkrankungen

Plasma endothelin in normal persons and in patients with various diseases

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Summary

Plasma concentrations of the recently isolated potent vasoconstrictory peptide endothelin were measured in 382 patients. The investigations were performed by means of a sensitive radioimmunoassay specific for Endothelin-1, 2.

The results from 110 healthy volunteers displayed a normal range of 44.67±3.51 pg/ml. Significantly raised levels were found in 33 patients with chronic end-stage renal failure both before and after hemodialysis. In contrast, 35 patients with compensated renal insufficiency did not differ from the normals. Sixty-five patients after kidney transplantation revealed significantly elevated levels, as did 27 patients with acute myocardial infarction, 8 after coronary bypass surgery, and 5 with liver cirrhosis. The mean values of 27 patients with untreated hypertension, 22 with secondary hypertension, of various causes and 16 with coronary artery disease were comparable to the normal population. The values were significantly decreased in 9 pregnant women with hypertension and proteinuria. A marked decline was found in 5 patients with systemic lupus erythematodes, while 20 patients with rheumatoid arthritis demonstrated only a slight decrease.

The pathophysiological role of endothelin as a local or circulating hormone in regulating systemic blood pressure or release of other hormones remains to be determined.

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Abbreviations

KHK:

Koronare Herzerkrankung

EH:

Essentielle Hypertonie

SH:

Sekundäre Hypertonie

ANP:

Atrial natriuretic peptide

Bypass-OP:

Koronare Bypassoperation

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Authors and Affiliations

  1. Abteilung Nephrologie und Rheumatologie, Medizinische Universitätskliniken Göttingen, Deutschland

    J. Schrader, M. Borries, F. Ruschitzka, G. Schoel, M. Kandt, G. Warneke, C. Züchner, M. H. Weber, U. Neu & H. V. Henning

  2. Abteilung Kardiologie und Pulmonologie, Medizinische Universitätskliniken Göttingen, Deutschland

    U. Tebbe

  3. Universitätsfrauenklinik, Medizinische Universitätskliniken Göttingen, Deutschland

    W. Rath

Authors
  1. J. Schrader
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  2. U. Tebbe
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  3. M. Borries
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  4. F. Ruschitzka
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  5. G. Schoel
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  6. M. Kandt
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  7. G. Warneke
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  8. C. Züchner
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  9. M. H. Weber
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  10. U. Neu
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  11. W. Rath
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  12. H. V. Henning
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Additional information

Herrn Prof. Dr. med. F. Scheler zum 65. Geburtstag gewidmet.

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Schrader, J., Tebbe, U., Borries, M. et al. Plasma-Endothelin bei Normalpersonen und Patienten mit nephrologisch-rheumatologischen und kardiovaskulären Erkrankungen. Klin Wochenschr 68, 774–779 (1990). https://doi.org/10.1007/BF01647248

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  • DOI: https://doi.org/10.1007/BF01647248

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