Summary
Thirty hospitalized patients (22 men and eight women), aged between 15 and 41 years (mean = 25.4 years), with severe proven typhoid sepsis were treated with pefloxacin at daily dose of 1200 mg, divided in three doses, intravenously for the first five days and orally for the following ten days of treatment. All patients completely recovered from infection and pathogens were eradicated after 30 days of follow-up. In none of the patients was a relapse registered during the follow-up or enteric carrier state after disease. Pefloxacin therapy was well tolerated by all patients: in five patients a mild and transient epigastric pain and in one patient a mild and transient nausea were registered. Pefloxacin is a safe and effective agent for therapy of typhoid fever.
Zusammenfassung
30 stationäre Patienten mit gesichertem, septisch verlaufendem Typhus (22 Männer, acht Frauen; Alter 15 bis 41 Jahre, im Mittel 25,4 Jahre) erhielten fünf Tage lang Pefloxacin intravenös in einer Gesamttagesdosis von 1200 mg, aufgeteilt in drei Einzeldosen. Die Therapie wurde für weitere zehn Tage oral fortgesetzt. Alle Patienten haben sich von der Infektion vollständig erholt, nach einer Beobachtungszeit von 30 Tagen waren in allen Fällen die Erreger eliminiert. Während der Nachbeobachtungszeit war bei keinem der Patienten ein Rezidiv aufgetreten oder Erregerausscheidung im Stuhl festzustellen. Die Therapie war in fünf Fällen mit leichten, vorübergehenden epigastrischen Schmerzen und in einem Fall mit leichter, passagerer Übelkeit assoziiert. Pefloxacin ist ein sicheres und wirksames Medikament für die Behandlung des Typhus.
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Cristiano, P., Iovene, M.R., Simioli, F. et al. Clinical experience with pefloxacin in the therapy of typhoid fever. Infection 17, 86–87 (1989). https://doi.org/10.1007/BF01646882
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DOI: https://doi.org/10.1007/BF01646882