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Gastric emptying in non-responders to H2-receptor antagonists

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Summary

H2-receptor antagonists are known to fail to increase the intragastric pH in some patients (so-called non-responders), and we have recently found a higher frequency of non-responders among cirrhotics. Since intragastric pH is also affected by gastric emptying, in the present study we determined the gastric emptying of 300 ml orange juice labelled with [99mTc]-Solco Nanocoll using a gamma camera. Measurements were made over a period of 60 min in cirrhotic patients and controls without liver disease who either responded to 300 mg ranitidine or showed no response. The mean (±SD) liquid half-emptying time (T1/2) was 26.3±17.5 min (range, 9–75 min) in responders (n=10), 20.9±8.6 min (range, 7–34 min) in non-responders (n=10), 19.4±19.2 min (range, 7–75 min) in cirrhotics (n=11), and 27±4.6 min (range, 17–33 min) in controls (n=9). In 19 of the 20 subjects gastric emptying was normal (T 1/2, <40 min). Since gastric emptying was not delayed in any of the non-responders, it would appear very unlikely that gastric motility plays a major role in the non-response to H2-receptor antagonists.

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Abbreviations

MBq:

mega-Becquerel

SD:

standard deviation

Tc:

technetium

T1/2 :

Half-emptying time

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Authors and Affiliations

  1. Abteilung für Radiologie, Robert-Bosch-Krankenhaus, Stuttgart

    J. Meinke

  2. Institut für Klinische Pharmakologie, Robert-Bosch-Krankenhaus, Stuttgart

    U. Klotz

  3. Abteilung für Gastroenterologie, Robert-Bosch-Krankenhaus, Stuttgart

    S. Walker, G. Treiber & J. C. Bode

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  1. S. Walker
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  2. J. Meinke
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  3. U. Klotz
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  4. G. Treiber
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  5. J. C. Bode
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Walker, S., Meinke, J., Klotz, U. et al. Gastric emptying in non-responders to H2-receptor antagonists. Klin Wochenschr 68, 959–963 (1990). https://doi.org/10.1007/BF01646654

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  • DOI: https://doi.org/10.1007/BF01646654

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