Summary
In a prospective randomized study, the efficacy and safety of 1 and 2 g of cefodizime administered as single intramuscular injections were compared in a total of 50 women having either complicated or uncomplicated lower urinary tract infections (LUTI). Bacteriological culture of urine and safety laboratory tests were performed before and after treatment. 18/25 patients in the 1 g cefodizime group and 22/25 in the 2 g cefodizime group showed satisfactory clinical and bacteriological response to treatment. The inadequately treated patients all had complicating factors on entry to the study (residual urine in six cases, a bladder malignancy in two, neurogenic bladder and diabetes mellitus with glucosuria in one case each). Cefodizime proved efficacious in female patients with uncomplicated LUTI, as well as in those aged over 65 years, patients having mild renal insufficiency, mild glucosuria, unsuccessful oral antibiotic pretreatment or recurrent and postoperative infections. In no case were there any systemic adverse reactions to cefodizime or clinically significant changes in laboratory tests.
Zusammenfassung
In dieser prospektiven randomisierten Studie wurden die Wirksamkeit und Verträglichkeit einer Einmaldosis von 1 oder 2 g Cefodizim i.m. bei 50 Frauen mit Infektionen der unteren Harnwege untersucht. Vor und nach Behandlung wurden ein Harnstatus mit Urinbakteriologie sowie Laboruntersuchungen durchgeführt. In der Dosisgruppe 1 g wurden 18 von 25 Patienten geheilt, in der Dosisgruppe 2 g 22 von 25. Bei allen unzureichend behandelten Patientinnen war vor Therapiebeginn ein komplizierter Harnweginfekt festgestellt worden (sechsmal Restharn, zweimal ein Blasentumor und je einmal eine neurogene Blasenentleerungsstörung und eine Glukosurie bei Diabetes mellitus). Cefodizim war bei unkomplizierten Harnwegsinfektionen, aber auch bei Patientinnen über 65 Jahre, bei gering eingeschränkter Nierenfunktion, bei antibiotischer Vorbehandlung und bei rezidivierenden oder postoperativen Infektionen wirksam. Systemische Nebenwirkungen oder klinisch relevante Laborveränderungen wurden nicht beobachtet.
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Asbach, H.W. A randomized, dose comparison study of cefodizime in the treatment of lower urinary tract infections in women. Infection 19, 85–87 (1991). https://doi.org/10.1007/BF01645573
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DOI: https://doi.org/10.1007/BF01645573