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Acute hepatitis C virus superinfection followed by spontaneous HBeAg seroconversion and HBsAg elimination

Spontane Serokonversion gegen HBeAg und Elimination von HBsAg nach akuter Hepatitis C Virus Superinfektion

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Summary

Acute hepatitis C virus superinfection followed by spontaneous hepatitis B e antigen seroconversion and hepatitis B surface antigen clearance in a patient with chronic type B hepatitis is described. The observations suggests that HCV may exert a suppressive effect on hepatitis B virus.

Zusammenfassung

Nach akuter Superinfektion mit dem Hepatitis C Virus trat bei einem Patienten mit chronischer B Hepatitis eine Serokonversion gegen das Hepatitis B Virus e- Antigen und Elimination des Hepatitis B Virus Oberflächenantigens ein. Nach dieser Beobachtung könnte HCV eine suppressive Wirkung gegen das Hepatitis B Virus haben.

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References

  1. Choo, Q. L., Kuo, G., Weinger, A. J., Overby, L. R., Bradley, D. W., Houghton, M. Isolation of a DNA clone derived from a blood-borne non- A, non-B viral hepatitis genome. Science 244 (1989) 350–362.

    Google Scholar 

  2. Kuo, G., Choo, Q. L., Alter, H. J., Gitnick, G. L., Redeker, A. G., Purcell, R. H., Miyamura, T. An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science 244 (1989) 362–364.

    Google Scholar 

  3. Alter, H. J., Purcell, R. H., Shih, J. W., Melpolder, J. C., Houghton, M., Choo, Q. L., Kuo, G. Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis. N. Engl. J. Med. 321 (1990) 1494–1500.

    Google Scholar 

  4. Stevens, C. E., Taylor, P. E., Pindyck, J., Choo, Q. L., Bradley, D. W., Kuo, G., Houghton, M. Epidemiology of hepatitis C virus. A preliminary study in volunteer blood donors. JAMA 263 (1990) 49–53.

    Google Scholar 

  5. Chen, D. S., Kuo, G. C., Sung, J. L., Lai, M. Y., Sheu, J. C., Chen, P. J., Yang, P. M., Hsu, H. M., Chang, M. H., Chen, C. J., Hahn, L. C., Choo, Q. L., Wang, T. H., Houghton, M. Hepatitis C virus infection in an area hyperendemic for hepatitis B and chronic liver disease: The Taiwan experience. J. Infect. Dis. 162 (1990) 817–822.

    Google Scholar 

  6. Sanchez-Tapias, J. M., Barrera, J. M., Costa, J., Ercilla, M. G., Pares, A., Comalrrena, L., Soley, F., Bruix, J., Calvet, X., Gil, M. P., Mas, A., Bruguera, M., Castillo, R., Rodes, J. Hepatitis C virus infection in patients with nonalcoholic chronic liver disease. Ann. Intern. Med. 112 (1990) 921–924.

    Google Scholar 

  7. Liaw, Y. F., Chu, C. M., ChangChien, C. S., Wu, C. S. Simultaneous cute infections with hepatitis non-A, non-B and B viruses. Dig. Dis. Sci. 27 (1982) 762–764.

    Google Scholar 

  8. Tsiquaye, K. N., Portmann, B., Tovey, G., Kessler, H., Hu, S. L., Lu, X. Z., Zuckerman, A. J., Williams, R. Non-A, non-B hepatitis in persistent carriers of hepatitis B virus. J. Med. Virol. 11 (1983) 179–189.

    Google Scholar 

  9. Bradley, D. W., Maynard, J. E., McCaustland, K. A., Murphy, B. L., Cook, E. H., Ebert, J. W. Non-A, non-B hepatitis in chimpanzees: Interference with acute hepatitis A virus and chronic hepatitis B virus infections. J. Med. Virol. 11 (1983) 207–213.

    Google Scholar 

  10. Liaw, Y. F., Lin, S. M., Sheen, I. S., Chen, T. J., Chu, C. M. Treatment of chronic type B hepatitis in Southeast Asia. Am. J. Med. 85 (1988) S147–149.

    Google Scholar 

  11. Liaw, Y. F., Chu, C. M., Su, I. J., Huang, M. J., Lin, D. Y., Chang-Chien, C. S. Clinical and histological event preceding hepatitis B e antigen seroconversion in chronic type B hepatitis. Gastroenterology 84 (1983) 216–219.

    Google Scholar 

  12. Liaw, Y. F., Sheen, I. S., Chen, T. J., Chu, C. M., Pao, C. C. The incidence, determinants and significance of delayed clearance of hepatitis B surface antigen in chronic hepatitis B virus infection: A prospective study. Hepatology 13 (1991) 627–631.

    Google Scholar 

  13. Davis, G. L., Hoofnagle, J. H., Waggoner, J. G. Acute type A hepatitis during chronic hepatitis B virus infection: Association of depressed hepatitis B virus replication with appearance of endogenous alpha interferon. J. Med. Virol. 14 (1984) 141–147.

    Google Scholar 

  14. Ichimura, H., Tamura, I., Tsubakio, T., Kuoimura, O., Kuoimura, T. Influence of hepatitis delta virus superinfection on the clearance of hepatitis B virus (HBV) markers in HBV carriers in Japan. J. Med. Virol. 26 (1988) 49–55.

    Google Scholar 

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Authors and Affiliations

  1. Liver Unit, ChangGung Memorial Hospital, 199, Tung Hwa North Road, 10591, Taipei, Taiwan

    Y. F. Liaw M. D., S. M. Lin M. D., I. S. Sheen M. D. & C. M. Chu M. D.

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  1. Y. F. Liaw M. D.
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  2. S. M. Lin M. D.
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  3. I. S. Sheen M. D.
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  4. C. M. Chu M. D.
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Liaw, Y.F., Lin, S.M., Sheen, I.S. et al. Acute hepatitis C virus superinfection followed by spontaneous HBeAg seroconversion and HBsAg elimination. Infection 19, 250–251 (1991). https://doi.org/10.1007/BF01644957

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  • DOI: https://doi.org/10.1007/BF01644957

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