Summary
124 consecutive patients (mean age: 41.1 years; range: 20–63 years) attending an outpatient alcoholic clinic were tested for the presence of markes of HBV infection. HBsAg was found in 26 (21%), anti-HBs and/or anti-HBc in the absence of HBsAg in 35 (28%). Altogether, at least one marker was present in 61 (49%), these results being significantly higher than in a matched control population. In 70 cases HBV status was compared with epidemiological data. No relationship was found with past blood transfusions, hospitalization or jaundice. HBV infection was, however, more common when parents of the subjects were alcoholics, which points to a possible role of family spreading. Furthermore, chronic infection with HBV was related to high alcohol intake.
Zusammenfassung
Bei 124 aufeinanderfolgenden Patienten (mittleres Alter 41,1 Jahre; Bereich 20–63 Jahre) einer Alkoholikerambulanz wurden die Marker der HBV-Infektion bestimmt. In 26 Fällen (21%) fand sich HBsAg, bei 35 (28%) anti-HBs und/oder anti-HBc ohne HBsAg. Bei insgesamt 61 Patienten (49%) war mindestens ein Marker nachzuweisen. Diese Prävalenzen für HBV-Marker liegen signifikant über denen einer vergleichbaren Kontrollgruppe. In 70 Fällen wurde der HBV-Status mit epidemiologischen Daten verglichen. Es fand sich keine Beziehung zu vorausgegangenen Bluttransfusionen, stationärer Behandlung oder Ikterus. Doch war die HBV-Infektion häufiger, wenn die Eltern Alkoholiker waren, was auf die Möglichkeit einer Ausbreitung in der Familie hinweist. Es bestand außerdem eine Beziehung zwischen der chronischen HBV-Infektion und hohem Alkoholkonsum.
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Laskus, T., Lupa, E., Szczutowska, E. et al. Prevalence of hepatitis B virus markers among polish urban alcoholics. Infection 16, 354–357 (1988). https://doi.org/10.1007/BF01644546
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DOI: https://doi.org/10.1007/BF01644546