In vitro activity of flomoxef in comparison to other cephalosporins

Summary

Flomoxef and cefazolin had nearly the same activity against staphylococci, which was stronger than that of other cephalosporins. AgainstStreptococcus pyogenes, Streptococcus agalactiae andStreptococcus pneumoniae, cefotaxime and cefazolin were more active than flomoxef, but the other cephamycins were less active than flomoxef. In comparison to the other cephalosporins, latamoxef and flomoxef had higher activity againstBranhamella catarrhalis, whereas cefotaxime, latamoxef and cefotetan were more active againstHaemophilus influenzae. Flomoxef was the only drug exhibiting activity againstClostridium difficile. The activity of flomoxef and latamoxef againstBacteroides fragilis was stronger than that of the other cephalosporins, butBacteroides bivius was resistant to each of these antibiotics.

Zusammenfassung

Flomoxef und Cefazolin hatten gegen Staphylokokken ungefähr die gleiche Wirksamkeit, während die anderen Cephalosporine schwächer wirkten. GegenStreptococcus pyogenes, Streptococcus agalactiae undStreptococcus pneumoniae waren Cefotaxim und Cefazolin stärker wirksam als Flomoxef, jedoch war Flomoxef den anderen Cephamycinen überlegen. Im Vergleich zu den anderen Cephalosporinen waren Latamoxef und Flomoxef stärker wirksam gegenBranhamella catarrhalis, während Cefotaxim, Latamoxef und Cefotetan gegenHaemophilus influenzae aktiver waren. Flomoxef war das einzig wirksame Mittel gegenClostridium difficile. GegenBacteroides fragilis wirkten Flomoxef und Latamoxef am besten (nurBacteroides bivius war völlig resistent).