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Liposomes and nanoparticles as vehicles for antibiotics

Liposomen und Nanopartikel als Träger für Antibiotika

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Summary

Colloidal drug carriers such as liposomes and nanoparticles are easily taken up by phagocytic cells and accumulate in the organs of the reticuloendothelial system. Therefore, they hold promise as carriers for the treatment of intracellular infections with antibiotics that would normally not find easy access to intracellular sites. Consequently, inin vitro andin vivo experiments the therapeutic efficacy of substances such as amphotericin B, dihydrostreptomycin, amikacin, ampicillin, stibogluconate against a number of microorganisms includingLeishmania donovani, Candida albicans, Staphylococcus aureus, Mycobacterium avium, Listeria monocytogenes, andSalmonella typhimurium was increased significantly by binding to liposomes and nanoparticles.

Zusammenfassung

Kolloidale Arzneistoffträger wie Liposomen und Nanopartikeln werden leicht von phagozytierenden Zellen aufgenommen und reichern sich somit in den Organen des retikuloendothelialen Systems an. Aus diesem Grunde sind sie vielversprechende Träger für Antibiotika zur Therapie intrazellulärer Infektionen, die sonst kaum oder nicht in diese Zellen gelangen können. Entsprechend wurdein vitro wie auchin vivo durch Bindung von Substanzen wie Amphotericin B, Dihydrostreptomycin, Amikacin, Ampicillin und Wismutgluconat an Liposomen und Nanopartikeln eine wesentliche Verbesserung der therapeutischen Effizienz gegen eine Reihe von Mikroorganismen wieLeishmania donovani, Candida albicans, Staphylococcus aureus, Mycobacterium avium, Listeria monocytogenes, undSalmonella typhimurium erreicht.

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  1. Institut für Pharmazeutische Technologie der Johann Wolfgang Goethe-Universität, Georg-Voigt-Str. 16, W-6000, Frankfurt am Main, Germany

    J. Kreuter

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Kreuter, J. Liposomes and nanoparticles as vehicles for antibiotics. Infection 19 (Suppl 4), S224–S228 (1991). https://doi.org/10.1007/BF01644038

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