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A randomised prospective controlled study of ciprofloxacin with metronidazole versus amoxicillin/clavulanic acid with metronidazole in the treatment of intra-abdominal infection

Ciprofloxacin plus Metronidazol im Vergleich zu Amoxicillin/Clavulansäure plus Metronidazol zur Behandlung intraabdomineller Infektionen. Randomisierte, prospektive, kontrollierte Studie

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Summary

A prospective randomised study was undertaken in 80 patients to assess the combined regimen of ciprofloxacin with metronidazole against amoxicillin/clavulanic acid with metronidazole as treatment for established intra-abdominal infection. Treatment was for five days. Seventy-eight patients were clinically evaluable (38 patients on ciprofloxacin with metronidazole and 40 patients on amoxicillin/clavulanic acid with metronidazole). The overall clinical success rate in the treatment of intra-abdominal infections was 96% for the ciprofloxacin with metronidazole group, and 90% for the amoxicillin/clavulanic acid with metronidazole group. Over half of all patients were able to change from intravenous to oral antibiotic administration within the study period. One patient receiving ciprofloxacin with metronidazole developed pruritus near the injection site.

Zusammenfassung

80 Patienten mit gesicherter abdomineller Infektion wurden im Rahmen einer prospektiven randomisierten Studie entweder mit der Kombination Ciprofloxacin plus Metronidazol oder mit Amoxicillin/Clavulansäure plus Metronidazol behandelt; die Behandlungsdauer betrug fünf Tage. Zur klinischen Auswertung standen 78 Patienten zur Verfügung (38 Patienten waren mit Ciprofloxacin plus Metronidazol, 40 mit Amoxicillin/Clavulansäure plus Metronidazol behandelt worden). In der Ciprofloxacin-Metronidazol-Gruppe sprachen 96% der Patienten klinisch auf die Therapie an, in der Gruppe, die Amoxicillin/Clavulansäure plus Metronidazol erhalten hatte, 90%. Bei mehr als der Hälfte der Patienten konnte die Antibiotikatherapie nach anfänglicher intravenöser Gabe auf die orale Applikation umgestellt werden. Bei einem Patienten trat nach Gabe von Ciprofloxacin plus Metronidazol neben der Injektionsstelle Pruritus auf.

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Authors and Affiliations

  1. Department of Surgery, Kansai Medical University, Osaka, Japan

    K. Yoshioka M.D.

  2. Department of Microbiology, The General Hospital, B4 6NH, Birmingham, UK

    D. J. Youngs S.M.L.S.O.

  3. Department of Surgery, The General Hospital, B4 6NH, Birmingham, UK

    M. R. B. Keighley M.S., F.R.C.S.

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  1. K. Yoshioka M.D.
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  2. D. J. Youngs S.M.L.S.O.
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  3. M. R. B. Keighley M.S., F.R.C.S.
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Yoshioka, K., Youngs, D.J. & Keighley, M.R.B. A randomised prospective controlled study of ciprofloxacin with metronidazole versus amoxicillin/clavulanic acid with metronidazole in the treatment of intra-abdominal infection. Infection 19, 25–29 (1991). https://doi.org/10.1007/BF01643754

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