Summary
The new fluoroquinolones have not been tested in children despite their wide spectrum ofin vitro activity and efficacy, because of an observed damage to cartilage in young animals. However, in some cases they may be life-saving. We present three pediatric patients with life threatening infections in whom the fluoroquinolones were used when other antibiotics failed: A seven-year-old boy with meningitis due to multiresistantAcinetobacter calcoaceticus, a three-year-old boy with Job's syndrome with line sepsis due toStaphylococcus epidermidis and a four month-old boy with agammaglobulinemia with mixed infection due toEscherichia coli, Pseudomonas aeruginosa, andAcinetobacter spp. All three children were cured of their infections.
Zusammenfassung
Trotz ihres breiten Wirkungsspektrums und hoher Aktivitätin vitro wurden die neuen fluorierten Chinolone bei Kindern nicht therapeutisch erprobt, da bei jungen Tieren Knoprelläsionen beobachtet wurden. Sie können in bestimmten Fällen jedoch lebensrettend sein. Wir berichten über drei Kinder mit lebensbedrohlichen Infektionen, bei denen nach Versagen anderer Antibiotika fluorierte Chinolone eingesetzt wurden: bei einem siebenjährigen Jungen, der an einer Meningitis durchAcinetobacter calcoaceticus erkrankt war, einem dreijährigen Jungen mit Kathetersepsis durchStaphyloccus epidermidis bei Job-Syndrom und einem vier Monate alten Jungen mit Agammaglobulinämie, bei dem eine Mischinfektion durchEscherichia coli, Pseudomonas aeruginosa undAcinetobacter spp. aufgetreten war. Alle drei Kinder wurden von ihrer Infektion geheilt.
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Dagan, R., Schlaeffer, F. & Einhorn, M. Parenteral fluoroquinolones in children with life-threatening infections. Infection 18, 237–238 (1990). https://doi.org/10.1007/BF01643396
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DOI: https://doi.org/10.1007/BF01643396