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Inactivation of netilmicin by carbenicillin

Inaktivierung von Netilmicin durch Carbenicillin

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Summary

Netilmicin was added to human serum and stored at various temperatures and carbenicillin concentrations prior to bioassay. Inactivation of netilmicin increased with temperature and carbenicillin concentration. The order of inactivation of aminoglycosides was: tobramycin > gentamicin, netilmicin > amikacin.

Zusammenfassung

Netilmicin wurde Humanserum zugesetzt und vor der biologischen Auswertung bei verschiedenen Temperaturen und Carbenicillinkonzentrationen gelagert. Die Inaktivierung von Netilmicin nahm mit steigender Temperatur und Carbenicillinkonzentration zu. Die Inaktivierung von Aminoglykosiden ergab die Reihenfolge: Tobramycin > Gentamycin > Netilmicin > Amikacin.

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Authors and Affiliations

  1. Director of Microbiology, Veterans Administration Hospital 113, 921 Northeast 13th St., 73104, Oklahoma City, Oklahoma, USA

    D. J. Flournoy Ph.D.

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  1. D. J. Flournoy Ph.D.
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Flournoy, D.J. Inactivation of netilmicin by carbenicillin. Infection 6, 241 (1978). https://doi.org/10.1007/BF01642317

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  • DOI: https://doi.org/10.1007/BF01642317

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