Summary
The ability of clavulanic acid to inactivate β-lactamase was investigated using 47 amoxicillin-resistant bacteria. In the presence of 10 mg/l clavulanic acid most strains of staphylococci,Escherichia coli, Klebsiella andProteus mirabilis became fully amoxicillinsensitive. This effect of clavulanic acid was in most instances not observed withSerratia marcescens, Proteus inconstans, Pseudomonas aeruginosa, Enterobacter and indole-positiveProteus species.
Zusammenfassung
Die Fähigkeit von Clavulansäure, β-Lactamasen zu inaktivieren, wurde an 47 Amoxicillin-resistenten Bakterien untersucht. Bei einer Clavulansäurekonzentration von 10 mg/l wurden die meisten Staphylokokken-,Escherichia coli-, Klebsiella-undProteus mirabilis-Stämme voll Amoxicillin-empfindlich. Dieser Effekt von Clavulansäure konnte beiSerratia marcescens, Proteus inconstans, Pseudomonas aeruginosa, Enterobacter und Indol-positivenProteus spp. überwiegend nicht festgestellt werden.
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Peters, G., Pulverer, G. & Neugebauer, M. In vitro-activity of clavulanic acid and amoxicillin combined against amoxicillin-resistant bacteria. Infection 8, 104–106 (1980). https://doi.org/10.1007/BF01641472
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DOI: https://doi.org/10.1007/BF01641472