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Activity of ciprofloxacin (BAYo 9867) against pseudomonas aeruginosa and ampicillin-resistant Enterobacteriaceae

Wirksamkeit von Ciprofloxacin (BAYo 9867) bei Pseudomonas aeruginosa und Ampicillin-resistenten Stämmen von Enterobacteriaceae

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Summary

We studied thein vitro activity of ciprofloxacin against 570 strains of ampicillin-resistantEnterobacteriaceae and 286Pseudomonas aeruginosa strains. 95.26% of theEnterobacteriaceae and 53.45% of theP. aeruginosa were inhibited by 0.1 mg/l of ciprofloxacin. 2 mg/l of ciprofloxacin inhibited all of theEnterobacteriaceae strains and 4 mg/l all of theP. aeruginosa. We compared the activity of ciprofloxacin with that of temocillin in theEnterobacteriaceae strains. In theP. aeruginosa strains, classified according to their susceptibility to carbenicillin and gentamicin, we compared the activity of ciprofloxacin with that of ceftazidime. In the strains studied, thein vitro activity of ciprofloxacin is superior to that of temocillin against theEnterobacteriaceae and to that of ceftazidime against theP. aeruginosa strains.

Zusammenfassung

Es wurde die Wirksamkeitin vitro von Ciprofloxacin bei 570 Ampicillin-resistentenEnterobacteriaceae- und 286Pseudomonas aeruginosa-Stämmen untersucht. 95,26% derEnterobacteriaceae- und 53,45% derP. aeruginosa-Stämme wurden mit 0,1 mg/l Ciprofloxacin gehemmt. 2 mg/l von Ciprofloxacin hemmten alleEnterobacteriaceae-Stämme und 4 mg/l alleP. aeruginosa-Stämme. Bei denEnterobacteriaceae-Stämmen wurde die Wirksamkeit von Ciprofloxacin mit der von Temocillin verglichen. Bei den nach Carbenicillin- und Gentamicin-resistenten Isolaten klassifiziertenP. aeruginosa-Stämmen verglichen wir die Aktivität von Ciprofloxacin und Ceftazidim. Bei den den untersuchtenEnterobacteriaceae-Stämmen ist die Wirksamkeit von Ciprofloxacinin vitro höher als die von Temocillin und bei denP. aeruginosa-Stämmen höher als die von Ceftazidim.

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Authors and Affiliations

  1. Departamento de Microbiologia de la Facultad de Medicina de la Universidad Autónoma de Barcelona, Bellaterra (Barcelona), Spain

    C. Roy,  A. Foz,  M. Tirado,  M. Teixell &  D. Teruel

  2. Instituto Municipal de Investigación Médica, Paseo Maritimo, s/n, Barcelona-3, Spain

    C. Segura

Authors
  1. C. Roy
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  2. A. Foz
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  3. C. Segura
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  4. M. Tirado
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  5. M. Teixell
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  6. D. Teruel
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Roy, C., Foz, A., Segura, C. et al. Activity of ciprofloxacin (BAYo 9867) against pseudomonas aeruginosa and ampicillin-resistant Enterobacteriaceae. Infection 11, 326–328 (1983). https://doi.org/10.1007/BF01641358

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  • DOI: https://doi.org/10.1007/BF01641358

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