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Cefsulodin in der Therapie der Pseudomonasmeningitis

Cefsulodin for the treatment of meningitis due to Pseudomonas aeruginosa

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Zusammenfassung

Drei Patienten mit Meningitiden durchPseudomonas aeruginosa (bei einer Patientin im Gefolge eines neurochirurgischen Eingriffes und bei zwei Patienten nach Schädeltraumen mit Frakturen und Liquorrhoe) wurden mit Cefsulodin in Kombination mit anderen Antibiotika (Aminoglykosiden/Acylureidopenicillinen) behandelt. Alle drei Patienten konnten geheilt werden. Zwei Patienten erhielten zusätzlich zur systematischen Antibiotikagabe Aminoglykoside intraventrikulär appliziert. In einem dieser Fälle konnte ein trotz intraventrikulärer Aminoglykosidgabe aufgetretenes Rezidiv erst nach zusätzlicher intraventrikulärer Applikation von Cefsulodin ausgeheilt werden. Der dritte Patient wurde mit alleiniger systemischer Gabe von Cefsulodin und Amikacin geheilt. Der Wert von Cefsulodin wird unter Berücksichtigung von erreichbaren ventrikulären und lumbalen Liquorkonzentrationen erörtert.

Summary

Three patients with meningitis due toPseudomonas aeruginosa (in one patient following a neurosurgical procedure and in two patients following severe head trauma with multiple skull bone fractures and liquorrhea) were treated with cefsulodin in combination with other antibiotics (aminoglycosides/acylureido penicillins). All of the patients were cured. Two patients received intraventricular administrations of aminoglycosides in addition to systemically applied antibiotics. After recurrence of pseudomonas meningitis in one patient in spite of the intraventricular application of an aminoglycoside, definite cure could only be obtained by additional intraventricular application of cefsulodin. The third patient was cured by systemic administration of cefsulodin and amikacin. The value of cefsulodin is discussed with reference to obtainable ventricular and lumbar CSF concentrations.

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Authors and Affiliations

  1. Infektionsabteilung des Klinikums Charlottenburg der Freien Universität Berlin, Spandauer Damm 130, D-1000, Berlin 19, Germany

    O. Brückner &  M. Trautmann

  2. Neurochirurgische Abteilung des Klinikums Charlottenburg der Freien Universität Berlin, Spandauer Damm 130, D-1000, Berlin 19, Germany

    H. Collmann

Authors
  1. O. Brückner
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  2. M. Trautmann
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  3. H. Collmann
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Brückner, O., Trautmann, M. & Collmann, H. Cefsulodin in der Therapie der Pseudomonasmeningitis. Infection 11, 264–268 (1983). https://doi.org/10.1007/BF01641258

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