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Antibiotic resistance in various medical services

Antibiotika-Resistenz in verschiedenen medizinischen Versorgungsbereichen. Eine Computer-assistierte Untersuchung

A computer-assisted study

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Summary

The analysis of differences in occurrence of antibiotic-resistant strains belonging to ten species of “problem” bacteria was performed by means of a computer program in more than 150,000 bacterial strains isolated in Slovakia in 1977. In all respects, strains isolated in general medical practice were considerably more sensitive to classical as well as to newer antibiotics. Marked differences in resistance within individual medical services could be a reflection of both quantitative and qualitative aspects of the use of a given antibiotic. Urological and surgical wards, and in some respects pediatric and infectious diseases services, rendered the highest percentage of strains resistant to various drugs. There are still several antibiotics which are effective in vitro against staphylococci, while gentamicin, colistin and cotrimoxazole are the only antibiotics displaying more general activity against gram-negative “problem” bacteria. Nevertheless, strains from general practice show a good response in vitro, even to older antibiotics, despite the fact that these have been widely used for decades in general practice.

Zusammenfassung

Die Analyse des unterschiedlichen Vorkommens von antibiotika-resistenten Stämmen, die zu zehn Spezies von „Problem“-Bakterien gehören, wurde mit Hilfe eines Computerprogrammes bei mehr als 150 000 Bakterienstämmen durchgeführt, die 1977 in der Slowakei isoliert wurden. In jeder Beziehung waren die Stämme, die in der Allgemeinpraxis isoliert wurden, wesentlich empfindlicher gegenüber den klassischen und neueren Antibiotika. Bedeutende Unterschiede in der Resistenz-Situation zwischen den einzelnen medizinischen Versorgungsbereichen könnten quantitative und qualitative Aspekte der Verwendung eines bestimmten Antibiotikums wiederspiegeln. Urologische und chirurgische Stationen und zum Teil pädiatrische und Infektionsabteilungen übersandten den höchsten Prozentsatz von gegenüber verschiedenen Substanzen resistenten Stämmen. Es gibt immer noch mehrere Antibiotika, die in vitro gegen Staphylokokken wirksam sind, während Gentamicin, Colistin und Cotrimoxazol die einzigen Antibiotika sind, die eine breitere Aktivität gegen gramnegative „Problem“-Bakterien aufweisen. Desungeachtet zeigen Stämme aus der Allgemeinpraxis eine gute Ansprechbarkeit in vitro, sogar gegenüber älteren Antibiotika, obwohl diese seit Jahrzehnten in der Allgemeinpraxis in großem Umfang verwendet worden sind.

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Krčméry, V., Grunt, J., Osival, L. et al. Antibiotic resistance in various medical services. Infection 7 (Suppl 2), S216–S219 (1979). https://doi.org/10.1007/BF01641126

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  • DOI: https://doi.org/10.1007/BF01641126

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