Summary
This paper deals with the immuno-pathological characteristics of tick-borne encephalitis. With the appearance of neurological signs, there is a strong T cell reaction in the peripheral blood. The following seven days are characterized by the appearance of a specific cell-mediated reaction in the peripheral blood; in the cerebrospinal fluid, an increasing number of B cells and specific antibodies can be detected. After a week, the percent positivity of cell-mediated immune reactions is higher and there is a T cell dominance in the cerebrospinal fluid. Intact cellular immunity against specific antigen is required for the management of this disease. There are major differences in the results obtained from patients suffering from meningitis alone and those suffering from meningoencephalitis.
Zusammenfassung
Die immunpathologischen Charakteristika der Zecken-Enzephalitis wurden untersucht. Zum Zeitpunkt des Auftretens neurologischer Symptome findet sich im peripheren Blut eine ausgeprägte T-Zell-Reaktion. Die folgenden sieben Tage sind durch eine spezifische zellvermittelte Reaktion im peripheren Blut gekennzeichnet. Im Liquor cerebrospinalis findet sich hingegen eine zunehmende Anzahl von B-Zellen und spezifischen Antikörpern. Nach einer Woche findet sich ein höherer Anteil positiver zellvermittelter Immunreaktionen und eine T-Zell-dominanz im Liquor cerebrospinalis. Für einen normalen Krankheitsverlauf ist eine intakte zelluläre Immunität gegen spezifisches Antigen nötig. Es war festzustellen, daß wesentliche Unterschiede zwischen dem Untersuchungsergebnis von Patienten, die an Meningitis litten und jenen, die eine Meningoenzephalitis durchmachten, bestanden.
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Sipos, J., Gábor, V., Tóth, Z. et al. Investigations on blood and cerebrospinal fluid lymphocytes in patients suffering from tick-borne encephalitis. Infection 9, 258–263 (1981). https://doi.org/10.1007/BF01640987
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DOI: https://doi.org/10.1007/BF01640987